Research Program Members

Martina Bazzaro, PhD
Assistant Professor

612-626-3111
mbazzaro@umn.edu

Development of targeted therapies for treatment of ovarian and HPV-associated cervical cancer; development and characterization of new biomarkers for early-detection ovarian cancer; identification and characterization of molecules associated with ovarian cancer development and progression; the role of angiogenesis in ovarian cancer progression

Full bio

John Bischof, PhD
Professor

612-625-5513
bischof@umn.edu

Thermal biology and nanotechnology to develop novel therapies to treat cancer

Full bio

Erin Dickerson, PhD
Associate Professor

612-626-5053
edickers@umn.edu

Targeted therapy using peptides in conjunction with novel delivery approaches; development of targeted delivery strategies that overcome drug resistance of tumors and strategies that target the drivers of tumor formation and maintenance

Full bio

William Elmquist, PharmD, PhD
Professor

612-625-0097
elmqu011@umn.edu

Biochemical and physiological determinants of drug absorption, distribution, and elimination with a focus on brain tumors

Full bio

Michael Garwood, PhD
Professor

612-626-2001
gar@cmrr.umn.edu

Developing advanced MRI and MRS spectroscopy techniques to study tissue function, metabolism and microstructure to better understand the unique functional and molecular properties of cancer, and to improve the clinical management of the disease

Full bio

Emily Greengard, MD
Assistant Professor

612-626-2778
emilyg@umn.edu

Full bio

Edward Greeno, MD
Professor

612-624-0123
green048@umn.edu

Clinical management of gastrointestinal malignancies

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Kalpna Gupta, PhD
Professor

612-625-7648
gupta014@umn.edu

Opioid/opioid receptor signaling in endothelium leading to preclinical and translational studies to investigate the role of opioids and opioid receptor antagonists in angiogenesis, cancer progression and metastasis; basic and translational studies to prevent this inadvertent effect of opioids without compromising analgesia

Full bio

Pankaj Gupta, MD
Professor

612-467-4135
gupta013@umn.edu

The role of proteglycans in stem cell niche formation; association of opioid use with clinical outcomes in prostate cancer, including cancer progression and survival

Full bio

Shilpa Gupta, MBBS
Assistant Professor

612-624-5620
guptash@umn.edu

Development of novel targeted therapies and immunotherapy combinations in gladder, prostate and kidney cancers; role of androgen receptor (AR) in bladder cancer.

Full bio

Bin He, PhD
Professor

612-626-1115
binhe@umn.edu

Application of functional electrencephalography, thermography and fMRI to the detection of physiologically relevant signals such as pain and normal and tumor cell migration

Full bio

Luke Hoeppner, PhD
Assistant Professor

507-437-9623
lhoeppner@hi.umn.edu

Molecular mechanisms and signal transduction pathways involved in vascular permeability, lung cancer progression/metastasis, and cancer drug resistance using in vitro, murine, and zebrafish models as well as human samples

Full bio

Ningling Kang, PhD
Assistant Professor

507-437-9680
nkang@hi.umn.edu

Full bio

Molly Klein, MD
Assistant Professor

612-273-5848
meklein@umn.edu

Surgical pathologist with interest in breast and gynecologic cancers

Full bio

Dan Knights, PhD
Assistant Professor

​612-524-2762
knights@umn.edu

The role of the pretreatment of gut microbiota in predicting and preventing chemotherapy-related bloodstream infection and sepsis; role of colon cancer tumor microenvironment bacteria in predicting tumor progression and mutation profiles

Full bio

Jessica Lawrence, DVM, DACVIM, DACVR, DECVDI, MRCVS
Associate Professor, Department of Veterinary Clinical Sciences

jlawrenc@umn.edu

Developing methods of improving radiation dose within tumors while minimizing toxicity and identification of radiation-induced changes within tumor and normal tissue microenvironments

Full bio

Aaron LeBeau, PhD
Assistant Professor

612-301-7231
alebeau@umn.edu

Targeting cancer-associated proteases for imaging and therapy using small-molecule and antibody-based inhibitors; main expertise in prostate cancer

Full bio

Danni Li, PhD
Assistant Professor

612-626-0299
dannili@umn.edu

Carbohydrate modified proteins as clinical diagnostics; cancer biomarkers, proteomics, assay development

Full bio

Fang Li, PhD
Associate Professor

612-625-6149
lifang@umn.edu

Structures and functions of mammalian-cell-surface enzymes that are critical for tumor cell growth; development of novel therapy strategies to treat human diseaes

Full bio

Emil Lou, MD, PhD, FACP
Assistant Professor

612-625-1110
emil-lou@umn.edu

Investigation of tumor heterogeneity and intercellular communication in a spectrum of invasive and aggressive solid tumor malignancies; biology of cancer cells as they relate to cancer cell invasion, progression, tumor recurrence, and chemotherapy resistance; the role of TnTs as an important mode of intercellular communication in cancer and in tumor-stromal cross-talk in the complex and heterogeneous tumor microenvironment.

Full bio

Kevin Mayo, PhD
Professor

612-625-9968
mayox001@umn.edu

Molecular structural characterization using NMR for the development of anti-angiogenic therapies; development of molecules that disrupt tumor angiogenesis and extracellular glycoproteins important in tumor migration and adhesion

Full bio

James McCarthy, PhD
Professor

612-625-7454
mccar001@umn.edu

Changes in the relationships between tumor cells and the surrounding extracellular matrix in tumor progression and metastasis, focusing on melanoma and prostate cancer; hyaluronan synthesis in prostate tumor growth, invasion, and metastasis to bone and other organs

Full bio

Greg Metzger, PhD
Associate Professor

612-626-2001
gmetzger@cmrr.umn.edu

Development of a prostate imaging program at the Center for Magnetic Resonance Research with the initial goal to investigate the potential of magnetic resonance imaging and spectroscopy to noninvasively determine the extent and aggressiveness of prostate cancer in clinical studies

Full bio

Javed Mohammed, PhD
Assistant Professor

612-624-5664
amohamme@umn.edu

Mechanisms of TGF beta signaling in malignant progression of squamous cell carcinomas.

Full bio

Paari Murugan, MD
Assistant Professor

612-273-5465
pmurugan@umn.eduu

Surgical pathologist with research interests focused on genitourinary cancers.

Full bio

Hiroshi Nakato, PhD
Associate Professor

612-625-1727
nakat003@umn.edu

Roles of heparan sulfate proteoglycans (HSPGs) in developmental processes such as growth factor signaling, morphogen gradient formation, and stem cell niche, using Drosophila genetics as our model

Full bio

Andrew Nelson, MD, PhD
Assistant Professor

612-273-3328
nels2055@umn.edu

Mechanisms driving tumor initiation and progression; development of comprehensive diagnostic platforms using integrated morphologic, immunohistochemical, and molecular information.

Full bio

David Odde, PhD
Professor

612-626-9980
oddex002@umn.edu

Cellular and molecular bioengineering in cancer

Full bio

Brenda Ogle, PhD
Associate Professor

ogle0008@umn.edu

Mechanisms of stem cell differenatiation; generation oif new technologies that advance stem cell biology and promote translation of stem cell research into clinical practice

Full bio

Paolo Provenzano, PhD
Assistant Professor

612-624-3279
pprovenz@umn.edu

Molecular mechanisms by which the stromal extracellular matrix and stromal cell populations influence epithelial cell behavior in cancer; understanding the complex interactions of biochemical factors, matrix architecture and matrix mechanical properties especially as they pertain to progression in breast and pancreatic cancer

Full bio

Emilian Racila, MD
Assistant Professor

612-273-5976
evracila@umn.edu

Isolation, characterization and relevance of circulating tumor cells for prognosis and therapy; role of complement system in cancer and autoimmune response development; molecular signatures of malignancies; vaccine development; molecular mutations in malignant mesothelioma

Full bio

Mohammad Saleem, PhD
Assistant Professor

507-437-9662
msbhat@hi.umn.edu

Understanding the biochemical, cellular, and molecular processes crucial for the development of prostate and pancreatic cancer; identification of potential agents that could be used to treat and prevent cancer in humans

Full bio

Kaylee Schwertfeger, PhD
Associate Professor

612-626-9419
schwe251@umn.edu

Mechanisms through which infiltrating inflammatory cells and their soluble mediators contribute to mammary tumor formation

Full bio

Aubie Shaw, PhD
Assistant Professor

218-726-6657
akshaw@d.umn.edu

Interaction between 3 cells types in the tumor microenvironment (carcinoma cells, fibroblasts and myeloid cells) in mediating tumor metastasis

Full bio

Donald A. Simone, PhD
Professor

612-625-6464
simon003@umn.edu

Mechanisms of cancer pain associated with bone metastasis and chemotherapy-induced neuropathy

Full bio

Amy Skubitz, PhD
Professor

612-625-5920
skubi002@umn.edu

Basic mechanisms associated in ovarian cancer spread, and the interactions of beta-1 integrin subunits and CD44 on the surfaces of ovarian carcinoma cells and mesothelial cells; identification of biomarkers that can be used for detection and prognosis of ovarian cancer

Full bio

Daniel Vallera, PhD
Professor

612-626-6664
valle001@umn.edu

Development of novel anticancer therapeutics focusing on the genetic engineering of cancer biologicals as alternative therapies for drug refractory cancer

Full bio

Michael Wilson, PhD
Associate Professor

612-467-2810
wilso042@umn.edu

How cell surface proteolysis modulates the tumor microenvironment to facilitate cancer growth, invasion, and metastasis

Full bio

David Wood, PhD
Assistant Professor

612-624-1438
dkwood@umn.edu

Development of in vitro tumor models that incorporate key microenvironmental cues that affect tumor development as well as the unique vascular architecture to better understand the process of metastasis - how cancer cells spread through the vasculature from one site to another, as well as how nanoparticles carrying chemotherapeutics or gene silencing siRNA, re most efficiently delivered to a tumor.

Full bio

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