Research Program Members
Development of targeted therapies for treatment of ovarian and HPV-associated cervical cancer; development and characterization of new biomarkers for early-detection ovarian cancer; identification and characterization of molecules associated with ovarian cancer development and progression; the role of angiogenesis in ovarian cancer progression
Targeted therapy using peptides in conjunction with novel delivery approaches; development of targeted delivery strategies that overcome drug resistance of tumors and strategies that target the drivers of tumor formation and maintenance
Developing advanced MRI and MRS spectroscopy techniques to study tissue function, metabolism and microstructure to better understand the unique functional and molecular properties of cancer, and to improve the clinical management of the disease
Opioid/opioid receptor signaling in endothelium leading to preclinical and translational studies to investigate the role of opioids and opioid receptor antagonists in angiogenesis, cancer progression and metastasis; basic and translational studies to prevent this inadvertent effect of opioids without compromising analgesia
Molecular mechanisms and signal transduction pathways involved in vascular permeability, lung cancer progression/metastasis, and cancer drug resistance using in vitro, murine, and zebrafish models as well as human samples
The role of the pretreatment of gut microbiota in predicting and preventing chemotherapy-related bloodstream infection and sepsis; role of colon cancer tumor microenvironment bacteria in predicting tumor progression and mutation profiles
Associate Professor, Department of Veterinary Clinical Sciences
Developing methods of improving radiation dose within tumors while minimizing toxicity and identification of radiation-induced changes within tumor and normal tissue microenvironments
Investigation of tumor heterogeneity and intercellular communication in a spectrum of invasive and aggressive solid tumor malignancies; biology of cancer cells as they relate to cancer cell invasion, progression, tumor recurrence, and chemotherapy resistance; the role of TnTs as an important mode of intercellular communication in cancer and in tumor-stromal cross-talk in the complex and heterogeneous tumor microenvironment.
Changes in the relationships between tumor cells and the surrounding extracellular matrix in tumor progression and metastasis, focusing on melanoma and prostate cancer; hyaluronan synthesis in prostate tumor growth, invasion, and metastasis to bone and other organs
Development of a prostate imaging program at the Center for Magnetic Resonance Research with the initial goal to investigate the potential of magnetic resonance imaging and spectroscopy to noninvasively determine the extent and aggressiveness of prostate cancer in clinical studies
Molecular mechanisms by which the stromal extracellular matrix and stromal cell populations influence epithelial cell behavior in cancer; understanding the complex interactions of biochemical factors, matrix architecture and matrix mechanical properties especially as they pertain to progression in breast and pancreatic cancer
Isolation, characterization and relevance of circulating tumor cells for prognosis and therapy; role of complement system in cancer and autoimmune response development; molecular signatures of malignancies; vaccine development; molecular mutations in malignant mesothelioma
Basic mechanisms associated in ovarian cancer spread, and the interactions of beta-1 integrin subunits and CD44 on the surfaces of ovarian carcinoma cells and mesothelial cells; identification of biomarkers that can be used for detection and prognosis of ovarian cancer
Development of in vitro tumor models that incorporate key microenvironmental cues that affect tumor development as well as the unique vascular architecture to better understand the process of metastasis - how cancer cells spread through the vasculature from one site to another, as well as how nanoparticles carrying chemotherapeutics or gene silencing siRNA, re most efficiently delivered to a tumor.