Research Program Members

Paul Bohjanen, MD, PhD
Professor of Medicine

612-625-7679
bohja001@umn.edu

Role of mRNA decay in regulating T cell activation and function

Full bio

Michael Farrar, PhD
Professor

612-625-0401
farra005@umn.edu

How cytokines and cytokine-dependent signal transduction pathways control regulatory T cell development and B cell leukemia

Full bio

Brian Fife, PhD
Assistant Professor

612-624-2417
bfife@umn.edu

The PD-1 negative regulatory pathway in T cells and its role in controlling autoimmunity and preventing transplant rejection

Full bio

Tanya Freedman, PhD
Assistant Professor

612-301-8313
tfreedma@umn.edu

How inflammation modulates macrophage responsiveness, including in the inflammatory tumor microenvironment, especially in breast cancer; the regulation of proto-oncogenic signaling proteins like the Src family kinases

Full bio

Rachel Gibbons Johnson, PhD
Assistant Professor

320-589-6326
rmjohns@morris.umn.edu

The role of B7-H1 (PD-L1) expressed by tumor cells in negatively regulated anti-tumor CD8 T cell responses

Full bio

Thomas Griffith,  PhD
Associate Professor

612-624-8269
tgriffit@umn.edu

The immunotherapeutic potential of TRAIL in preclinical models of advanced renal cell carcinoma and breast cancer

Full bio

Sara Hamilton, PhD
Assistant Professor

612-625-1626
hamil062@umn.edu

CD8 T cell activation, T cell memory generation and maintenance, enhancing protective immunity, inhibiting T cell pathology

Full bio

Kristin Hogquist, PhD
Professor

612-625-1616
hogqu001@umn.edu

Molecular mechanisms of T cell development in the thymus; analysis of transgenic and gene-deficient mice, gene expression profiling, and RNAi "knock-down" analysis;immune response to the Epstein Barr Virus - a chronic viral infection associated with cancer and autoimmunity in humans

Full bio

Stephen Jameson, PhD
Professor

612-625-1496
james024@umn.edu

Mechanisms that regulate the development and maintenance of T cells in the body; T cell homeostasis in response to lymphopenia which offers an opportunity to enhance the function of residual T cells in lymphodepleted individuals, including cancer patients receiving radio- or chemotherapy

Full bio

Marc Jenkins, PhD
Distinguished McKnight University Professor Director

612-626-2715
jenki002@umn.edu

Investigation of CD4 helper T and B cell activation in vivo by directly tracking antigen-specific cells, with the goal of achieving a basic understanding of lymphocyte signal transduction, proliferation, and differentiation so that these processes can be manipulated to improve vaccines and prevent autoimmunity

Full bio

Ryan Langlois, PhD
Assistant Professor

612-625-3633
langlois@umn.edu

The interplay between innate and adaptive immune responses in the lung; mechanisms that drive immunopathology, cell death/survival and healing within the lung

Full bio

Walter C. Low, PhD
Professor

612-626-9203
lowwalt@umn.edu

Development of immunotherapeutic approaches for the treatment of brain tumors

Full bio

David Masopust, PhD
Associate Professor

612-625-4666
masopust@umn.edu

Resident memory T cells, cytotoxic T cell migration and function within tissues, and CD8 T cell vaccines

Full bio

Jeffrey Miller, MD
Professor

612-625-7409
mille011@umn.edu

How undifferentiated stem cells develop into functioning NK cell lymphocytes and the manipulation of NK cells to treat or prevent cancer relapse; targeted immunotherapy to treat human cancer

Full bio

Christopher Moertel, MD
Professor

612-625-3229
moert001@umn.edu

Clinical interests include pediatriac neuro-oncology; rare pediatric tumors; neurofibromatosis-associated neoplasia; and the therapy of children with brain and spinal cord tumors.

Full bio

Daniel Mueller, MD
Professor

612-625-1155 Danie
muell002@umn.edu

Biological and biochemical nature of immune self-tolerance and application to the treatment of autoimmune disease, allograft rejection, and immunotherapy of cancer

Full bio

Michael Olin, PhD
Assistant Professor, Division of Pediatric Hematology and Oncology

612-624-3514
olin0012@umn.edu

Development of inhibitors derived to overcome the suppressive tumor microenvironment.

Full bio

Christopher Pennell, PhD
Associate Professor

612-625-7138
penne001@umn.edu

Enhancing the efficacy of DNA-based vaccines for cancer therapy

Full bio

Erik J. Peterson, MD
Associate Professor

612-625-1155
peter899@umn.edu

The role of adaptor proteins in T cell development, regulation of T cell-dependent autoimmunity, and immune cell transduction

Full bio

Liz Pluhar, DVM, PhD, Diplomate
Professor

612-625-1162
pluha006@umn.edu

Gene therapy for glioblastoma multiforme (GBM) and developing dogs with spontaneous glioma as an exceptional large animal model for human GBM and mengingiomas

Full bio

Daniel Saltzman, MD, PhD
Professor

612-626-4214
saltz002@umn.edu

Development of an attenuated strain ofSalmonella typhimurium as an anti-cancer therapy capable of local delivery of immunostimulatory cytokines

Full bio

Yoji Shimizu, PhD
Distinguished University Teaching Professor

612-626-6849
shimi002@umn.edu

Intracellular signal transduction events that regulate adhesion interactions critical for effective antigen-specific immune responses and cell trafficking

Full bio

Vaiva Vezys, PhD
Assistant Professor

612-625-4650
vvezys@umn.edu

Investigation of how T cell tolerance to self-antigens, tumor antigens, and proteins from chronic infections is induced and maintained; development of methods for reversing established tolerance to these types of proteins and their translation to the clinic

Full bio

Bruce Walcheck, PhD
Professor

612-624-2282
walch003@umn.edu

Mechanisms that direct leukocytes to tissue locations and that regulate inflammation and cancer cell killing

Full bio

Chun Wang, PhD
Associate Professor

612-626-3990
wangx504@umn.edu

Development of novel polymer-based biomaterials for the delivery of cancer chemo- and immunotherapeutics

Full bio

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