Research Program Members

Khalil Ahmed, PhD
Professor

612-467-2594
ahmedk@umn.edu

Functional role of protein kinase CK2 in cancer cells, employing prostate cancer and head-and-neck cancer as experimental models.

Full bio

Peter Argenta, MD
Associate Professor and Director

612-626-6037
argenta@umn.edu

Early events in carcinogenesis and the treatment and prevention of ovarian cancer, with specific interest in using antiangiogenic agents in the management of metastatic tumors.

Full bio

Vivian Bardwell, PhD

612-626-7028
bardw001@umn.edu

The role of transcription factors in cancer and development.

Full bio

Yue Chen, PhD
Assistant Professor

612-626-3340
yuechen@umn.edu

Development and application of powerful proteomic technologies in combination with biochemistry, cell biology and computational analysis to understand the dynamic profiles of the PTM networks in various diseases, and reveal the correlation between cellular metabolism and diverse PTM pathways.

Full bio

Scott Dehm, PhD
Associate Professor

612-625-1504
dehm@umn.edu

Role of the androgen receptor in prostate cancer development and progression

Full bio

Yibin Deng, MD, PhD
Associate Professor

507-437-9611
yiden@hi.umn.edu

Understanding how p53 controls apoptosis, senescence, and autophagy upon stress signals, and how p53 mutations that disrupt these processes impact tumor development and cancer therapy in vivo

Full bio

Barry Finzel, PhD
Professor and Director of Graduate Studies

612-626-5979
finze007@umn.edu

Structural biology research aimed at accelerating the development of medicinal agents and specific inhibitors of drug targets to advance the understanding of disease control, specifically to improve nucleoside pro-drug activation and to discover antagonists of CD44-mediated cell adhesion for improved cancer chemotherapy.

Full bio

Gunda Georg, PhD
Professor and Head

612-626-6320
georg@umn.edu

Design, synthesis, and evaluation of synthetic and natural product-derived medicinal agents; drug discovery by HTS; new synthetic methods; combinatorial chemistry

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Peter Gordon, MD
Assistant Professor

612-625-0711
gord0047@umn.edu

Development of approaches for overcoming bone marrow stromal cell mediated chemoresistance in AML and how factors secreted by cells within the leukemia microenvironment impact leukemia development and response to therapy

Full bio

Sergio Gradilone, PhD

507-437-9628
sgradilo@umn.edu

The role of primary cilia in tumor biology; mechanisms and consequences of ciliary loss in cholangiocarcinoma and pancreatic, prostate and breast tumors

Full bio

Shilpa Gupta, MBBS
Assistant Professor

612-624-5620
guptash@umn.edu

Developing novel targeted therapies and immunotherapy combinations in bladder, prostate and kidney cancers; early phase clinical trials using targeted and immunotherapy agents, including checkpoint inhibitors; the role of androgen receptor (AR) in bladder cancer.

Full bio

Timothy C. Hallstrom, PhD
Assistant Professor

612-626-2905
halls026@umn.edu

Cellular mechanisms controlling Rb/E2F induced apoptosis during normal proliferation and in cancer development

Full bio

Daniel Harki, PhD
Associate Professor

612-625-8687
daharki@umn.edu

Design, synthesis and biophysical characterization of small molecules that influence cellular function

Full bio

Luke Hoeppner, PhD

507-437-9623
lhoeppner@hi.umn.edu

Molecular mechanisms and signal transduction pathways involved in vascular permeability, lung cancer progression/metastasis, and cancer drug resistance using in vitro, murine, and zebrafish models as well as human samples.

Full bio

Ameeta Kelekar, PhD
Associate Professor

612-625-3204
ameeta@umn.edu

Pathways of cell survival and death with special emphasis on Bcl-2 family proteins as regulators of these pathways

Full bio

Do-Hyung Kim, PhD
Associate Professor

612-626-3418
dhkim@umn.edu

Understanding the molecular networks that coordinate nutrient metabolism and cell growth

Full bio

Badrinath Konety, MD, MBA
Department Chair

612-625-1655
brkonety@umn.edu

Urologic oncology; urinary markers for bladder cancer; new diagnostics techniques for prostate cancer; development of novel agents including gene therapy for prostate cancer

Full bio

Carol Lange, PhD
Professor

612-626-0621
lange047@umn.edu

Mechanisms of cancer progression involving signal transduction cross talk with steroid hormone receptors in breast, lung, and ovarian cancer models; role of MAPKs as major inputs to ligand-dependent and -independent progesterone receptor action and target gene selection in breast cancer; role of Brk/PTK6 actions upstream of ERK5 and p37 MAPK stress signalling pathways in breast tumor progression/ hypoxia

Full bio

Cheuk Leung, PhD
Assistant Professor

null
ctleung@umn.edu

Mammary tumor initiation from normal tissue, and signaling of tumor dormancy and recurrence utilizing expertise in 3D organotypic models, molecular tool design for single-cell manipulation, 4D live imaging, and 3D screening platform development

Full bio

Faqian Li, MD, PhD
Professor

612-273-4185
lif@umn.edu

Rose of the canonical Wnt pathway and epigenetic modifications in development and adult diseases; how signaling pathways interact with chromatic remodeling complex to modulate epigenome and gene expression

Full bio

Douglas G. Mashek, PhD
Professor

621-626-2904
dmashek@umn.edu

Lipid and energy metabolism and their role in development of non-alcoholic fatty liver disease, Type 2 diabetes, and obesity; characterization of pathways of lipid metabolism in cancer biology

Full bio

Thomas Neufeld, PhD
Associate Professor

612-625-5158
neufe003@umn.edu

Developmental mechanisms, genetic mechanisms, cell interactions, signal transduction, cell cycle regulation

Full bio

Julie Ostrander, PhD
Assistant Professor

612-625-1996
hans1354@umn.edu

Identification of biomarkers to identify pre-invasive breast cancer and response to chemoprevention

Full bio

Laurie Parker, PhD
Associate Professor

612-624-9066
llparker@umn.edu

Development of probes and biomarker analysis strategies for detecting therapeutic efficacy with a current focus on companion diagnostics to measure pharmacodynamics of kinase inhibitor drugs in leukemia; development of new directions to use cutting edge proteomics to study oxidative stress and potential prostate (and other) cancer biomarkers.

Full bio

Valerie Pierre, PhD
Associate Professor

612-625-0921
pierre@umn.edu

Design and synthesis of new molecules and materials for a targeted function; understanding the interplay among metals, reactive species, and cellular function in the brain and in tumors

Full bio

Vitaly Polunovsky, PhD
Professor

612-626-2112
polun001@umn.edu

The role of mRNA cap-dependent translation in breast cancer

Full bio

William Pomerantz, PhD
Assistant Professor

612-624-9091
wcp@umn.edu

Modulation of protein-protein interactions of intrinsically disordered proteins by developing chemical probes and structural biology tools for studying the role of these interactions in disease and developing new therapeutics

Full bio

David Potter, MD, PhD
Associate Professor

612-625-8933
dapotter@umn.edu

Potential role for the HIV protease inhibitor, ritonavir, as a modulator of PI2-kinase/AKT signaling in breast cancer and the development of new therapeutic approaches to breast cancer based on its function. Also of interest are the mechanisms of calpain proteases in cell motility and cytoskeletal remodeling.

Full bio

Ahmad Raza, MD
Adjunct Assistant Professor

612-624-0123
razax019@umn.edu

Basic science researech focused on lung cancer and mesothelioma; oversight of clinical trials at community oncology clinics

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James Robinson, PhD
Assistant Professor & Section Leader

507-437-9645
jrobinson@hi.umn.edu

Development a systematic approach for the identification and validation of stromal signaling pathways responsible for the promotion, maintenance, metastasis, and chemoresistance of cancer

Full bio

Teresa Rose-Hellekant, DVM, PhD
Director

218-726-6621
trosehel@d.umn.edu

Natural history of mammary cancer development; identification of molecular and cellular targets of tamoxifen chemoprevention; role of developmental genes in breast carcinogenesis; anticancer gene therapy and utility of mesenchymal stem cells; mouse modeling of cancer to study novel therapeutic and preventive drugs

Full bio

Deepali Sachdev, PhD
Assistant Professor

612-626-9420
sachd003@umn.edu

Regulation of breast cancer biology by the insulin-like growth factors (IGFs) and the IGF-1 receptor

Full bio

Casim A. Sarkar, PhD
Associate Professor

612-626-0525
csarkar@umn.edu

Cell signaling and decision making; engineering molecular and cellular cancer therapies

Full bio

Aubie Shaw, PhD
Assistant Professor

218-726-6657
akshaw@d.umn.edu

Full bio

Jill Siegfried, PhD
Professor and Head

612-624-2584
jsiegfri@umn.edu

Role of growth factors and hormones in the development and growth of lung cancer and the effects of these cytokines on control of tumor growth, their role in risk for cancer, and their signaling pathways; current focus is on estrogen, progesterone, EGF peptides, and hepatocyte growth factor.

Full bio

Jeffrey Simon, PhD
Professor

612-626-5097
simon004@umn.edu

Animal development; control of gene expression; chromatin mechanisms; the role of EZH2 gene in mammary development; epigenetic alterations that cause cancer

Full bio

Keith Skubitz, MD
Professor

612-624-5944
skubi001@umn.edu

Drug development and clinical trials, including the use of genomics to identify new drug targets and predict disease outcome

Full bio

Jimmie Stewart, III, MD
Associate Professor

612-273-5758
jstewart@umn.edu

Full bio

Anna Sundborger, PhD
Assistant Professor

507-437-9647
asundborger@hi.umn.edu

Structural insight into the assembly and function of membrane remodeling complexesmolecular mechanisms that control essential intracellular membrane remodeling and trafficking events, such as endo-lysosomal trafficking, apoptosis, autophagy and regulation of mitochondrial dynamics

Full bio

Carston Wagner, PhD
Professor and Endowed Chair

612-625-2614
wagne003@umn.edu

Rational design of novel anti-cancer therapeutics and nanotechnology based drug delivery systems by employing medicinal organic synthesis, immunology protein engineering, biochemistry and molecular modelling; Characterization of arylamine amine carcinogen metabolizing enzymes

Full bio

Da-Qing Yang, PhD
Assistant Professor

507-279-3048
dyang@hi.umn.edu

Signal transduction of ATM protein kianses in response to insulin and metformin in both diabetes and cancer; mechanisms of tumor suppressor gene function and cancer development, specifically regulation of p53 induction in response to DNA damage.

Douglas Yee, MD
Professor

612-626-8487
yeexx006@umn.edu

Understanding the contribution of insulin-like growth factor (IFG) action to the breast cancer malignant phenotype; experimental new therapies for breast cancer.

Full bio

David Zarkower, PhD
Professor and Director

612-625-9450
zarko001@umn.edu

DM domain gene function and role in human disease, including testicular cancer.

Full bio

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