Lawrence Afrin, MD

Professor of Medicine, Division of Hematology, Oncology and Transplantation

Lawrence Afrin

Contact Info

Administrative Assistant Name
Nancy Russell

Administrative Phone

Administrative Email

Administrative Fax Number

Professor of Medicine, Division of Hematology, Oncology and Transplantation


Medical School, Medical University of South Carolina, Charleston S.C.

Residency, Medical University of South Carolina, Charleston S.C.

Fellowship, Medical University of South Carolina, Charleston S.C.


Dr. Afrin earned a B.S. in Computer Science at Clemson University in 1984 and then an M.D. at the Medical University of South Carolina (MUSC) in 1988, where he also pursued internal medicine residency and hematology/oncology clinical and research fellowships. While on faculty at MUSC 1995-2014, he was active in undergraduate and graduate medical education, educational and IT administration, and practice and research in hematology/oncology and medical informatics. Since the mid-’00s, his clinical work has increasingly focused in hematology, especially mast cell disease; he also directed MUSC’s myeloproliferative neoplasms clinical trials program. He joined the University of Minnesota in 2014. He has served on national panels on oncology education and quality care and speaks widely in his areas of focus. He has an extensive record of peer-reviewed publications and serves on the editorial boards for several journals and on the Medical Advisory Board for The Mastocytosis Society.

Awards & Recognition

  • America's Best Doctors (2009-present)
  • Professional Associations

    • Medical Advisory Board, The Mastocytosis Society
    • Member, American Society of Hematology
    • Member, American Society of Clinical Oncology


    Research Summary/Interests

    Mast cell disease, especially mast cell activation syndrome; Chronic myeloproliferative neoplasms; Medical informatics


    • Afrin LB, Pöhlau D, Raithel M, Haenisch B, Dumoulin FL, Homann J, Mauer UM, Harzer S, Molderings GJ (2015). Mast Cell Activation Disease: An Underappreciated Cause of Neurologic and Psychiatric Symptoms and Diseases. Brain Behav Immun 2015, PMID: 26162709.
    • Afrin LB (2015). The Good, The Bad, and The Ugly of the New Doctor-Patient-Computer Relationship of the 21st Century. Journal of the South Carolina Medical Association, 2015 June, , PMID: pending.
    • Afrin LB, Cichocki F, Patel K, Molderings GJ (2015). Successful treatment of mast cell activation syndrome with sunitinib. Eur J Haematol 2015, PMID: 26072665, in press. .
    • Afrin LB, Khoruts A (2015). Mast cell activation disease and microbiotic interactions. Clin Ther 2015 May, PMID: 25773459, in press.
    • Randall N, Courville EL, Baughn L, Afrin L, Ustun C (2015). Bosutinib, A Lyn/Btk-Inhibiting Tyrosine Kinase Inhibitor, Is Ineffective In Advanced Systemic Mastocytosis. American Journal of Hematology 2015, PMID: 25641616, in press.



    • Hematology/Oncology


    Masonic Cancer Center;University of Minnesota Medical Center

    Board Certifications

    American Board of Internal Medicine; Hematology; Oncology

    Clinical Interests

    Benign hematology; Medical informatics; Mast cell disease, especially mast cell activation syndrome; Chronic Myeloproliferative neoplasms; Hematologic Malignancies; Hematology / Oncology