Malgorzata Marjanska, PhD

Associate Professor, CMRR

Malgorzata Marjanska

Contact Info

gosia@umn.edu

Office Phone 612-625-4894

Associate Professor, CMRR


Summary

Magorzata (Gosia) Marjaska is an Assistant Professor in the Department of Radiology. Dr. Marjaska received a B.S. in chemistry with minor in mathematics from Loyola University of Chicago and a Ph.D. in chemistry from the University of California at Berkeley. She joined the Center for Magnetic Resonance Research (CMRR) in 2002 as a post-doctoral fellow working with Prof. Kamil Ugurbil and subsequently became a research assistant professor two years later, and assistant professor in 2013.

Dr. Marjaska first encountered magnetic resonance while working with Prof. Keith Jameson at Loyola University of Chicago, first learning and then training other undergraduates to operate a 300 MHz Varian system. During the summer after her 3rd year of undergraduate studies, she worked at Bell Laboratories with Dr. Peter Mirau on solid state NMR characterization of polymer films. In order to follow her interest in NMR, she decided to pursue a Ph.D. at the University of California at Berkeley in the group of Prof. Alexander Pines. Her thesis titled “Quantum Logic Gates, Local Field, Selective Excitation and Structural Studies of Dipolar Couplings in Oriented Molecules” was focused on NMR as a technique to study molecules dissolved in liquid crystals.

In her work at CMRR, Dr. Marjaska is interested in:

  • 1H spectroscopy in humans (brain and other parts of the body) and rodents including development of spectroscopy techniques over a wide range of field strengths (3 T up to 16.4 T), quantification approaches and methods, and applications of spectroscopy to various diseases such as Alzheimer's disease and dystonia
  • T2 relaxation of neurochemicals at different field strengths (4 T and 7 T)
  • characterization of animal models of Alzheimer's disease using magnetic resonance in order to search for biomarkers that have the potential to be used in humans
  • evaluation of magnetic resonance as outcome measures for detecting disease modification
  • hyperpolarization of 13C labeled probes for the study of brain metabolism and function
  • imaging of contrast agents.

Research

Publications

  • M Marja?ska, T Z Teisseyre, N W Halpern-Manners, Y Zhang, I Iltis, V Bajaj, K Ugurbil, A Pines, P-G Henry, "Measurement of Arterial Input Function in Hyperpolarized 13C Studies", Appl Magn Reson 43 (2012) 289-297.
  • E D Smolensky, M Marjanska, V C Pierre, "A responsive particulate MRI contrast agent for copper (I): optimal cluster size for maximum response", Dalton Trans 41 (2012) 8039-8046. PMID: 22582342
  • D Deelchand, P-G Henry, K Ugurbil, and M Marja?ska, "Measurement of transverse relaxation times of J-coupled metabolites in the human visual cortex at 4 T", Magn Reson Med 67 (2012) 891-897. PMID: 21748799
  • M Marja?ska, E J Auerbach, R Valabrègue, P-F Van de Moortele, G Adriany, M Garwood, "Localized 1H NMR Spectroscopy in Different Regions of Human Brain In Vivo at 7 T: T2 Relaxation Times and Concentrations of Cerebral Metabolites", NMR Biomed 25 (2012) 332- 339. PMID: 21796710
  • M Marjanska, I Iltis, A A Shestov, D K Deelchand, C Nelson, K Ugurbil, P-G Henry, "In Vivo 13C Spectroscopy in the Rat Brain using Hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate", J Magn Reson 206 (2010) 210-218. PMID: 2068514
  • M Marjanska, P-G Henry, K Ugurbil, R Gruetter, "Editing through Multiple Bonds: Threonine Detection", Magn Reson Med 59 (2008) 245-251.
  • M C Dobre, K Ugurbil, M Marjanska, "Determination of the Blood Relaxation Time (T1) at High Magnetic Field Strengths", Magn Reson Imaging 25 (2007) 733-735.
  • M Marjanska, G L Curran, T M Wengenack, P-G Henry, R L Bliss, J F Poduslo, C R Jack Jr., K Ugurbil, M Garwood, "Monitoring Disease Progression in Transgenic Mouse Models of Alzheimer's Disease with Proton Magnetic Resonance Spectroscopy", Proc Nat Acad Sci USA 102 (2005) 11906-11910.
  • L Li, M Marjanska, G H J Park, A Pines and A P Alvisatos, "Isotropic-Liquid Crystalline Phase Diagram of CdSe Nanorod Solution", J Chem Phys 120 (2004) 1149-1152.
  • M Marjanska, F Castiglione, J D Walls, and A Pines, "Measurement of Dipolar Couplings in Partially Oriented Molecules by Local Field NMR Spectroscopy with Low-Power Decoupling", J Magn Reson 158 (2002) 52-59.
  • M Marjanska, I L Chuang, and M G Kubinec, "Demonstration of Quantum Logic Gates in Liquid Crystal Nuclear Magnetic Resonance", J Chem Phys 12 (2000) 5095-5099.