Zohar Sachs, MD, PhD

Lois and Richard King Assistant Professor of Medicine, Division of Hematology, Oncology and Transplantation

Zohar Sachs

Contact Info

sachs038@umn.edu

Mailing Address:
Division of Hematology, Oncology and Transplantation
420 Delaware Street SE
MMC 480
Minneapolis, MN 55455

Administrative Assistant Name
Sarah Strommer

Administrative Phone
612-625-9604

Administrative Email
strom721@umn.edu

Medical School, Tufts University School of Medicine, Boston, MA

Residency, Caritas St. Elizabeth's Medical Center, Boston, MA

Fellowship, University of Minnesota, Minneapolis, MN

Summary

Dr. Zohar Sachs received her undergraduate degree, a BS in Chemical Engineering, from the Massachusetts Institute of Technology (Cambridge). She then attended the Tufts Medical School Medical Scientist Training Program (Boston), receiving an MD/PhD. Dr. Sachs completed her residency in Internal Medicine at Caritas St. Elizabeth’s Medical Center (Boston). Dr. Sachs conducted her fellowship in Hematology, Oncology and Transplantation at the University of Minnesota. In 2012, she joined the faculty as a physician-scientist.

Dr. Sachs leads a basic and translational research lab focused on identifying the molecular mechanisms of self-renewal in acute myelogenous leukemia. Dr. Sachs specializes in the care of patients with hematological malignancies.

Research

Research Summary/Interests

Acute myeloid leukemia stem calls
My lab’s goal is to identify molecular mechanisms of leukemia stem cell self-renewal in primary murine and human acute myeloid leukemia (AML). Self-renewal is a feature of leukemia stem cells that allow them to recapitulate leukemia and cause relapse. Since AML cells are highly heterogenous, we specialize in the application of single-cell, high throughput technologies (including mass cytometry/CyTOF and single-cell RNA sequencing) to address these research questions.

My earlier work demonstrated that the activated NRAS oncogene mediates self-renewal in AML and that individual leukemia cells vary significantly in their functional status and ability to self-renew (Sachs et al. Blood 2014). Recently, we defined the gene expression profile of AML self-renewal at the single-cell level and used this data to identify a functionally unique subset of leukemia cells with leukemia-repopulating potential. We are using these approaches to identify effective therapeutic targets for this deadly disease.

Publications

Peer-Reviewed Publications:

  1. Csizmar CM, Kim DH, Sachs Z, The Role of the proteasome in AML. Blood CancerJournal. 2016;6(12)e503. PMID: 27911437 PMCID:PMC5223148 DOI:10.1038/bcj.2016.112 URL:http://www.nature.com/bcj/journal/v6/n12/full/bcj2016112a.html
  2. Trottier BJ, Sachs Z, DeFor TE, Shune L, Dolan M, Weisdorf DJ, Ustun C, Warlick ED. Novel disease burden assessment predicts allogeneic transplantation outcomes in myelodysplastic syndrome. Bone Marrow Transplant. 2016;51(2):199-204. PMCID: PMC5319562
  3. Mostecki J, Halgren A, Radfar A, Sachs Z, Ravitz J, Thome KC, Rosenberg N. Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells. J Virol 2000;74(20):9479-87. PMID: 11000217. PMCID: PMC 112377.
  4. Berretta S, Sachs Z, Graybiel AM. Cortically driven Fos in the striatum is amplified by local dopamine D2-class receptor blockade. Eur J Neurosci. 1999;11:4309-19. PMID 10594656. book chapter
  5. Courville EL, Sachs Z, Linden MA. Standardized synoptic reports for plasma cell neoplasms: integration of laboratory and clinical data. . In: Plasma Cell Neoplasms: A morphologic, cytogenetic, and Immunophenotypic approach. Linden MA, McKenna RW, editors. New York, NY: Springer; 2015.

Clinical

Specialties

  • Cancer
  • Hematology/Oncology

Clinics

Masonic Cancer Center

Board Certifications

  • Hematology

Clinical Interests

AML; Myeloid malignancies; Leukemia; Bone marrow diseases; Lymphoma; Myelodysplastic syndrome; Multiple Myeloma; Other Plasma Cell Neoplasm