Kelsey McIntyre, PhD

Assistant Professor, Department of Laboratory Medicine and Pathology

Kelsey McIntyre

Contact Info

mcintyrk@umn.edu

Office Phone 612-625-5468

Mailing Address:
MMC 609 Mayo
420 Delaware St. SE
Minneapolis, MN 55455

Clinical Molecular Genetics Fellow, Harvard Medical School, 2018

Clinical Cytogenetics Fellow, Harvard Medical School, 2017

PhD, University of Wisconsin-Madison, 2015

BS, University of Wisconsin-Madison, 2009

ABMGG Diplomate Certified in Clinical Cytogenetics and Clinical Molecular Genetics and Genomics

Summary

Dr. McIntyre is a cytogeneticist, molecular geneticist, and a member of the Division of Molecular Pathology and Genomics. McIntyre is an Associate Director in the UMMC Cytogenetics Laboratory and Molecular Diagnostics Laboratory.

McIntyre’s research interest is in the genetic mechanisms underlying cancer progression and response to therapy. Her studies have focused on myeloid malignancies, which are driven by recurrent somatic genetic alterations. McIntyre was involved in a study employing a clinically validated NGS assay to profile mutations, copy number changes, and genomic rearrangements in myeloid disorders. Correlation of molecular findings with those of conventional cytogenetics and fluorescence in situ hybridization uncovered benefits of an integrated testing approach. In many cases, unexpected findings lead to changes in diagnosis, prognosis, or therapeutic management. Once characterized, the genetic alterations then serve as markers for monitoring disease over time. Further, in some patients, molecular studies can detect low-level mutational burden revealing minimal residual disease in the context of morphologic and/or cytogenetic remission. McIntyre believes that these studies highlight the value of comprehensive genomic profiling, integrating cytogenetics and molecular diagnostics, in the management of myeloid malignancies and hopes to bring the approach into clinical practice.

Research

Publications

Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X. 2016. Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science 351(6274):707-10.

Branchfield K, Li R, Lungova V, Verheyden JM, McCulley D, Sun X. 2016. A three-dimensional study of alveologenesis in mouse lung. Developmental Biology 409(2):429-41.

Hines EA, Verheyden JM, Lashua AJ, Larson SC, Branchfield K, Domyan ET, Gao J, Harvey JF, Herriges JC, Hu L, Mcculley DJ, Throckmorton K, Yokoyama S, Ikeda A, Xu G, Sun X. 2016. Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis. Developmental Dynamics 245(4):497-507.

Lewis KJ, Tibbitt MW, Zhao Y, Branchfield K, Sun X, Balasubramaniam V, Anseth KS. 2015. In vitro model alveoli from photodegradable microsphere templates. Biomaterials Science 3(6):821-32.

Domyan ET*, Branchfield K*, Gibson DA, Naiche LA, Lewandoski M, Tessier-Lavigne M, Ma L, Sun X. 2013. Roundabout receptors are critical for foregut separation from the body wall. Developmental Cell 24(1):52-63. *equal contribution