Julia Davydova, MD, PhD

Associate Professor, Department of Surgery

Julia Davydova

Contact Info

davyd003@umn.edu

Office Phone 612-625-8608

Fax 612-624-9080

Office Address:
Department of Surgery
515 Delaware St
Moos Tower 11-204
Minneapolis, MN 55455

Associate Professor, Department of Surgery

Associate Professor, Department of Pharmacology


M.D., Siberian State Medical University. Tomsk, Russia (Medicine/Molecular Biology)

PhD, Siberian State Medical University and Research Institute of Pharmacology. Tomsk, Russia (Pathophysiology)

Postdoctoral Training, University of Alabama at Birmingham, Birmingham, AL. (Division of Human Gene Therapy) - Mentor: Dr. M. Yamamoto

Summary

Dr. Davydova's primary interest lies in the development of new oncolytic-virus based therapeutic and imaging modalities for pancreatic cancer, combination of oncolytic virus with immunotherapy and/or chemo-radiation to establish effective therapies for treatment-resistant cancer, and development of in vivo cancer models.

She received her M.D. and Ph.D. in Pathophysiology from the Siberian State Medical University in Tomsk, Russia. After teaching as a Lecturer and Senior Lecturer/Docent in the Biomedical Department at the Tomsk State Pedagogical University, she came to the U.S. to pursue her research interest in cancer gene therapy.

In 2000, she joined the Gene Therapy Center, University of Alabama at Birmingham (UAB) and obtained extensive training in adenoviral vector-based gene therapy at Curiel’s group. As a member of the UAB Division of Human Gene Therap she was directly involved in the development of new generations of Conditionally Replicative Adenoviruses (CRAds) for malignant diseases. Her contribution resulted in developing critical elements to improve infectivity and specificity of oncolytic virus therapy and led to significant advances of the utility of adenoviral vectors for various applications of human gene therapy.

In 2006 she joined the Department of Surgery at the University of Minnesota Medical School. She has attained invaluable experience in developing new therapeutic and imaging strategies for pancreatic cancer. Dr. Davydova actively expands virus-based gene delivery technologies via collaborations in varying clinical applications including cancer and stem cell, regenerative medicine, bone biology, mucosal immunity, diabetes, pancreatitis, and peptide hormone research

Professional Associations

American Society of Gene and Cell Therapy
American Association of Cancer Research
American Pancreatic Association
Japanese Society of Gene Therapy
Masonic Cancer Center, University of Minnesota, MN

Research

Research Summary/Interests

  • Gene Therapy Approaches for Cancer and Non-Malignant Diseases
  • Oncolytic Adenovirus for Cancer Therapy and Imaging
  • Sodium-Iodine Symporter (NIS)-mediated Radiotherapy and Imaging of Cancer
  • Pancreatic Cancer
  • In Vivo models of Pancreatic Cancer
  • Combination of Virotherapy with Radiation and Chemotherapy
  • Adenovirus-mediated Immunotherapy for Cancer
  • Viral Vectors as a Tool for Gene Delivery

Publications

  1. LaRocca CJ, Davydova J. Oncolytic Virotherapy Increases the Detection of Microscopic Metastatic Disease at Time of Staging Laparoscopy for Pancreatic Adenocarcinoma. EBioMedicine. May 2016;7:15-16. PMID: 27322450
  2. LaRocca C.; Han J.; Salzwedel A.; Davydova J; Herzberg M.C.; Gopalakrishnan R; Yamamoto M.Oncolytic adenoviruses Targete to Human Papilloma Virus-positive Head and neck Squamous Cell Carcinomas. Oral Oncol. 2016 May;56:25-31. doi: 10.1016/j.oraloncology.2016.02.014.. PMID: 27086483
  3. LaRocca C.; Han J.; Gavrikova T.; Armstrong L.; Oliveira A.; Shanley R.; Vickers S.M.; Yamamoto M.; Davydova J.Oncolytic adenovirus expressing interferon alpha in a syngeneic Syrian hamster model for the treatment of pancreatic cancer.Surgery. 2015 May; 157(5):888-98.doi:10.1016. PMID: 25731784.PMCID: PMC4417428
  4. KosakaT, Davydova J, Ono HA, Akiyama H, Hiri S, Ohno S, Takeshita F, Aoki K, Ochiya T, Yamamoto M, Kunisaki C, Endo I. Imaging and Antitumoral Effect of a Cyclo-oxygenase 2-specific Replicative Adenovirus for Small Metastatic Gastric Cancer Lesions. Anticancer Res. 2015 Oct; 35(10):5201-10. PMID: 26408678
  5. Huntley R, Davydova J, Petryk A, Billington CJ Jr, Jensen ED, Mansky KC, Gopalakrishnan R. The Function of Twisted Gastrulation in Regulating Osteoclast Differentiation is Dependent on BMP Binding. J Cell Biochem. 2015 Mar 24. doi: 10.1002/jcb.25174. PMID: 25808976
  6. Tasca A, Stemig M, Broege A, Huang B, Davydova J, Zwijsen A, Umans L, Jensen ED, Gopalakrishnan R, Mansky KC. Smad 1/5 and Smad 4 Expression Are Important for Osteoclast Differentiation. J Cell Biochem. 2015 Feb 24. doi: 10.1002/jcb.25092
  7. Davydova J, Yamamoto M. Oncolytic adenoviruses: design, generation, and experimental procedures. Curr Protoc Hum Genet.2014 Jul; Chapter 12:Unit12.14. PMID:2385308.
  8. Kimura J, Ono HA, Kosaka T, Nagashima Y, Hirai S, Ohno S, Aoki K, Julia D, Yamamoto M, Kunisaki C, Endo I. Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells. Cancer Sci; 2013 Aug;104(8):1083-90
  9. Yamasaki S., Miura Y., Davydova J., Vickers S., Yamamoto M. A single intraduodenal administration of human adenovirus 40 vaccine effectively prevents anaphylactic shock. Clin Vaccine Immunol. 2013 Jul 24. PMID: 23885027
  10. Fukuyama Y., Tokuhara D., Sekine S., Aso K., Kataoka K., Davydova J, Yamamoto M., Gilbert RS., Tokuhara Y., Fujihashi K., Kunisawa J., Yuki Y., Kiyono H., McGhee JR., Fujihashi K. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One. 2013;8(4):e60453. Epub 2013 Apr 2. PMID: 23565250.
  11. Mansky KC, Jensen ED, Davydova J, Yamamoto M, Gopalakrishnan R. Protein Kinase D Promotes In Vitro Osteoclast Differentiation and Fusion. J Biol Chem. 2013 Feb 21. PMID: 23430742.
  12. Oneal MJ, Trujillo MA, Davydova J, McDonough S, Yamamoto M, Morris JC 3rd. Effect of increased viral replication and infectivity enhancement on radioiodide uptake and oncolytic activity of adenovirus vectors expressing the sodium iodide symporter. Cancer Gene Ther. 2013 Mar;20(3):195-200. doi: 10.1038/cgt.2013.4. Epub 2013 Feb 15. PMID: 23412431.
  13. Miura Y., Yamasaki S., Davydova J.,Brown E., Aoki K., Vickers S., Yamamoto M. Infectivity-selective Oncolytic Adenovirus Developed by High-throughput Screening of Adenovirus-formatted Library. Mol Ther. 2013 Jan;21(1):139-48. PMID: 23032977
  14. Satoshi Yamasaki, Yoshiaki Miura, Julia Davydova, Selwyn Vickers, Masato Yamamoto. Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer. Int J. Cancer. 2012 Dec 11. doi: 10.1002/ijc.27983. PMID: 23233329
  15. Armstrong L, Arrington A, Han J, Gavrikova T, Brown E, Yamamoto M, Vickers SM, Davydova J. “Generation of a Novel, Cox2-Targeted, Interferon-Expressing, Conditionally-Replicative Adenovirus for Pancreatic Cancer Therapy”. American Journal of Surgery. 2012 Nov; 204(5):741-50. . PMCID: PMC3467355
  16. Yoshiaki Miura, Satoshi Yamasaki, Julia Davydova,Eric Brown, Kazunori Aoki, Selwyn Vickers, Masato Yamamoto. Infectivity-selective Oncolytic Adenovirus Developed by High-throughput Screening of Adenovirus-formatted Library. Mol. Ther. 2012 Oct 2. PMID: 23032977
  17. Oneal MJ, Trujillo MA, Davydova J, McDonough S, Yamamoto M, Morris JC.Characterization of infectivity-enhanced conditionally replicating adenovectors for prostate cancer radiovirotherapy. Hum Gene Ther 2012. Hum Gene Ther. 2012 Sep;23(9):951-9.
  18. Davydova J*, Armstrong L*, Brown E, Han J, Yamamoto M, Vickers S. Delivery of Interferon Alpha Using a Novel Cox2-Controlled Adenovirus for Pancreatic Cancer Therapy. Surgery. 2012 Jul;152(1):114-22. PMID: 22503318. PMCID: PMC3645277
  19. Y. Fukuyama,D. Tokuhara, S. Sekine, K. Kataoka, J. D. Markham, A. R. Irwin, G. H. Moon, Y. Tokuhara, K. Fujihashi, J. Davydova, M. Yamamoto, R. S. Gilbert, K. Fujihashi. Notch-ligand expression by NALT dendritic cells regulates mucosal Th1- and Th2-type responses. Biochem Biophys Res Commun. 2012 Feb 3;418(1):6-11.
  20. Lan Pham, Kayla Beyer, Eric Jensen, Julio Sotillo Rodriguez, Julia Davydova, Masato Yamamoto, Anna Petryk, Rajaram Gopalakrishnan, Kim Mansky. Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation. J Cell Biochem. 2011 Mar;112(3):793-803.
  21. Satoshi Yamasaki, Yoshiaki Miura, Eric Brown, Julia Davydova, Masato Yamamoto. Adenovirus Development of a method for effective amplification of human adenovirus 40. Arch. Virol. 2010 Jul;155(7):1059-68.
  22. Davydova J, Gavrikova T, Brown EJ, Luo X, Curiel DT, Vickers SM, Yamamoto M. In Vivo bioimaging tracks conditionally-replicative adenoviral replication and provides an early indication of antitumor efficacy. Cancer Sci. 2010 Feb;101(2):474-81
  23. Arrington AK, Davydova J, Vickers SM, Yamamoto M. Anti-ERBB2 sh-RNA suppress both cell growth and tumor growth in ERBB2-overexpressing upper gastrointestinal adenocarcinomas. J Gastrointest Surg. 2009 Oct;13(10):1754-61.
  24. Arrington AK, Dahlberg PS, Davydova J, Vickers SM, Yamamoto M. ERBB2 supression decreases cell growth via apoptosis in gastrointestinal adenocarcinomas. Surgery. 2009 Aug;146(2):213-9.
  25. Nelson AR, Davydova J, Curiel DT, Yamamoto M. Combination of conditionally replicative adenovirus and standard chemotherapies shows synergistic antitumor effect in pancreatic cancer. Cancer Sci. 2009 Jul 21.
  26. Trujillo M, Davydova J, Bergert E,Yamamoto M, Morris J. Construction of a MUC-1 Promoter Driven, Conditionally Replicating Adenovirus that Expresses the Sodium Iodide Symporter (NIS) for Gene Therapy of Breast Cancer. Breast Cancer Res. 2009 Jul 27;11(4):R53.
  27. Shinichi Sekine, Kosuke Kataoka, Yoshiko Fukuyama, Yasuo Adachi, Julia Davydova, Masato Yamamoto, Ryoki Kobayashi, Keiko Fujihashi, Hideaki Suzuki, David T. Curiel, Satoshi Shizukuishi, Jerry R. McGhee and Kohtaro Fujihashi. Novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. The Journal of Immunology. 2008 Jun 15; 180(12):8126-34.
  28. Ramírez PJ, Vickers SM, Ono HA, Davydova J, Takayama K, Thompson TC, Curiel DT, Bland KI, and Yamamoto M.Optimization of Conditionally Replicative Adenovirus for Pancreatic Cancer and its Evaluation in an Orthotopic Murine Xenograft Model. Am J Surg. 2008 Apr;195(4):481-90.
  29. M Yamamoto, N Nishimoto, J Davydova, T Kishimoto and D T Curiel. Suppressor of cytokine signaling-1 expression by infectivity-enhanced adenoviral vector inhibits IL-6-dependent proliferation of multiple myeloma cells. Cancer Gene Therapy. 2006 Feb;13(2):194-202
  30. Long P. Le, Helen N. Le, Igor P. Dmitriev, Julia G. Davydova, Tatyana Gavrikova, Seiji Yamamoto, David T. Curiel, Masato Yamamoto. Dynamic Monitoring of Oncolytic Adenovirus In Vivo by Genetic Capsid Labeling. Journal of the National Cancer Institute, February 1, 2006 Vol. 98, No. 3, 203-214.
  31. Hidetaka A. Ono, Long P. Le, Julia G. Davydova, Tatyana Gavrikova and Masato Yamamoto.Noninvasive Visualization of Adenovirus Replication with a Fluorescent Reporter in the E3 Region. Cancer Research.2005 Nov 15;65 (22):10154-8.
  32. Y. Tekant, J. Davydova, P. Ramirez, D. Curiel, S. Vickers, M. Yamamoto. Oncolytic adenoviral therapy in gallbladder carcinoma. Surgery. 2005 May;137(5):527-35.
  33. Ono HA, Davydova JG, Adachi Y, Takayama K, Barker SD, Reynolds PN, Krasnykh VN, Kunisaki C, Shimada H, Curiel DT, Yamamoto M. Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer. J Gastroenterol. 2005 Jan;40(1):31-42.
  34. A Rivera, J Davydova, S Schierer, M Wang, V Krasnykh, M Yamamoto, D T Curiel and D M Nettelbeck. Combining high selectivity of replication with fiber chimerism for effective adenoviral oncolysis of CAR-negative melanoma cells. Gene Therapy. 2004 Dec;11(23):1694-702.
  35. Davydova J, Le L.P., Gavrikova T., Wang M., Krasnykh V., Yamamoto M. Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma treatment. Cancer Research. 2004 Jul 15:64(12):4319-27.
  36. Le LP, Everts M, Dmitriev IP, Davydova JG, Yamamoto M, Curiel DT. Fluorescently labeled adenovirus with pIX-EGFP for vector detection. Mol Imaging. 2004 Apr;3(2):105-16.
  37. Yamamoto M, Davydova J, Wang M, Siegal GP, Krasnykh V, Vickers SM, Curiel DT. Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology. 2003 Oct;125(4):1203-18.
  38. Nettelbeck DM, Rivera AA, Davydova J, Dieckmann D, Yamamoto M, Curiel DT. Cyclooxygenase-2 promoter for tumour-specific targeting of adenoviral vectors to melanoma. Melanoma Res. 2003 Jun;13(3):287-92.
  39. Nagi P, Vickers SM, Davydova J, Adachi Y, Takayama K, Barker S, Krasnykh V, Curiel DT, Yamamoto M. Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement. J Gastrointest Surg. 2003 Mar-Apr;7(3):364-71.
  40. Yamamoto M, Davydova J, Takayama K, Alemany R, Curiel DT. Transcription initiation activity of adenovirus left-end sequence in adenovirus vectors with e1 deleted. J Virol. 2003 Jan;77(2):1633-7.
  41. Ugdyzhekova DS, Davydova YG, Maimeskulova LA, Mechoulam R. Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to epinephrine. Bull Exp Biol Med. 2000 Nov;130(11):1087-9. PMID: 11182823
  42. Ugdyzhecova DS, Maymeskulova LA, Davydova YG. Cannabinoid HU-210 increases cardiac tolerance to arrythmogenic effect of adrenaline and accinitine. Vestnik Arrythm. St.-Peterburg. 2000: V.19.p. 68-71.
  43. Davydova YG. Hemoglobinsynthetic function of erythron at intravasal laser therapy of women with acute inflammations of genitals. Actual Problems of Pharmacology and Search of New Drugs. 1995. V.8: p.101.
  44. Davydova YG, Makhmutkhodzhaev A. The functional characteristic of erythrocytes and neutrophiles in women with acute inflammation of uterus and Fallopian tubes. Ecogen. 1995. ? 5: p.39.

Text books:

  1. Davydova J, Yamamoto M. Oncolytic adenoviruses: design, generation, and experimental procedures. Curr Protoc Hum Genet. 2013 Jul; Chapter 12:Unit12.14. PMID:2385308.
  2. Nizkodubova S.V. Davydova J.G. Kulikova N.V. Human Physiology. Textbook for bio-medical students.2000. 68p.
  3. Kulikova N.V, Bernatskaya N.A, Bernatskii EO, Davydova J.G. The basics of human anatomy and pathophysiology. Textbook for students. 2000.138p.