Da-Qing Yang, PhD

Assistant Professor, The Hormel Institute, University of Minnesota,

Da-Qing Yang

Contact Info

dyang@hi.umn.edu

Office Phone 507-279-3048

Lab Phone 507-355-5257

Assistant Professor, The Hormel Institute, University of Minnesota


PhD, Biochemistry and Molecular Biology, Kansas State University

Summary

Dr. Yang is currently an assistant professor at the Hormel Institute, University of Minnesota and a member of the Masonic Cancer Center. His research focuses on signal transduction of the cytoplasmic ATM protein kinase and translational regulation of the p53 tumor suppressor.

Professional Associations

Member, Masonic Cancer Center, University of Minnesota

Research

Research Summary/Interests

Dr. Yang’s laboratory studies two important proteins, p53 and ATM, which are critical for multiple physiological processes, including cell cycle progression, DNA damage repair, insulin signal transduction, and glucose metabolism. Dr. Yang is a leading expert in signal transduction of the ATM protein kinase in response to insulin and metformin as their signals relate to both cancer and diabetes. He also works on the translational regulation of p53 induction following DNA damage in order to better understand how defective synthesis of the p53 tumor suppressor is involved in the development of cancer, including breast and prostate cancer. His group discovered the presence of an internal ribosome entry site (IRES) in the p53 mRNA that promotes cap-independent p53 translation in response to DNA damage and other cellular stress. Current research projects in the lab include the investigation of the effect of ATM on glucose uptake and glucose metabolism (the Warburg effect) in normal and cancer cells and the study of IRES-mediated p53 synthesis in order to develop novel diagnosis and treatment strategies for various types of cancer. 

Publications