Aubie Shaw, PhD

Assistant Professor, Medical School, Duluth Campus

Aubie Shaw

Contact Info

akshaw@d.umn.edu

Office Phone 218-726-6657

Lab Phone 218-726-6356

Office Address:
Department of Biomedical Sciences
207 SMed
1035 University Drive
Duluth, MN 55812

Assistant Professor, Medical School, Duluth Campus

Department of Biomedical Sciences


PhD, Cancer Biology, University of Wisconsin-Madison, 2007

MS, Biology/Cell Biology & Physiology, University of Minnesota Duluth, 2000

BS, University of Minnesota Duluth, 1998

Postdoctoral researcher, Vanderbilt-Ingram Cancer Center, 2007-2012

Postdoctoral researcher, Oregon Health & Science University, 2012-2013

Postdoctoral researcher, University of Minnesota Medical School Duluth campus, 2013-2015

Summary

Awards & Recognition

University of Minnesota Duluth

  • Outstanding Graduate Teaching Assistant, 1998
  • T. O. Odlaug Award for Outstanding Service to the Biology Department, 1997

External Sources

  • 2nd Prize for Outstanding Poster Presentation in Vanderbilt Postdoctoral, Research and Shared Resources Symposium $150, 2012
  • 1st Prize for Outstanding Poster Presentation in Vanderbilt Postdoctoral, Research and Shared Resources Symposium $300, 2011
  • AACR-Susan G. Komen Scholar-in-Training Award $1,000, 2010
  • Sigma Xi Outstanding Poster Award, 2002
  • Marshall H. and Nellie Alworth Memorial Scholarship $16,000, 1993
  • First Bank of Virginia College Scholarship $500, 1993
  • Virginia Rotary Club College Scholarship $500, 1993

Research

Research Summary/Interests

Research in the Shaw lab focuses on the interaction between three cell types in the tumor microenvironment (carcinoma cells, fibroblasts and myeloid cells) in mediating tumor metastasis. Our research has shown that secreted factors from myeloid cells encourage the invasion of fibroblasts (leader fibroblasts); and this directly increases carcinoma cell invasion. Although we have identified some proteins that mediate this activity, our current work is examining the roles of RNAs in exosomes.


Our work uses live cell microscopy to image cells in 3-dimensional constructs. Our current work uses CellMate3DTM, a chemically-defined tissue-like microenvironment composed of hyaluronic acid and chitosan (BRTI Life Sciences). BRTI Life Sciences is a local biotech company located in Two Harbors, MN and I work closely with BRTI researchers to develop novel therapeutics and cultivate local industry.

Publications

See full list of publications at: PubMed

Manuscripts:

Gast CE, Shaw AK, Wong MH, Coussens LM (2017) Surgical procedures and methodology for a preclinical murine model of de novo mammary cancer metastasis. J Vis Exp, 125 (e54852), 1-6. PMID 28784976.

Zanganeh S, Hutter G, Spitler R, Lenkov O, Mahmoudi M, Shaw A, Pajarinen J, Nejadnik H, Goodman S, Moseley M, Coussens L, Daldrup-Link H (2016) Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nature Nanotechnology, 2016 Sep 26. doi: 10.1038/nnano.2016.168. [Epub ahead of print] PMID: 27668795, PMCID:PMC5198777.

Daldrup-Link H, Mohanty S, Ansari C, Lenkov O, Shaw A, Ito K, Hong SH, Hoffmann M, Pisani L, Boudreau N, Gambhir S, Coussens L (2016) Alk5-inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors. JCI Insight, 2016 May 6;1(6). pii: e85608 PMID: 27182558, PMCID: PMC4864003.

Shaw AK, Kalem MC, Zimmer SL (2016) Mitochondrial Gene Expression Is Responsive to Starvation Stress and Developmental Transition in Trypanosoma cruzi. mSphere, 1(2): e00051-16 PMID: 27303725, PMCID: PMC4894683.

Shaw AK, Pickup MW, Chytil A, Aakre M, Owens P, Moses HL, Novitskiy SV (2015) TGF signaling on myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions. PLOS One, 10(1): e0117908 PMID: 25629162, PMCID: PMC4309578.

Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC, Moses HL (2013) Bone morphogenetic proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLOS One, 8(6): e76533 PMID: 23840733, PMCID: PMC3695869.

Johnson MD, Shaw AK, O’Connell MJ, Sim FJ, Moses HL (2011) Analysis of transforming growth factor receptor expression and signaling in higher grade meningiomas. J Neurooncol, 103(2): 277-285 PMID: 20853018.

Xu BJ, Yan W, Jovanovic B, Shaw AK, An QA, Eng J, Chytil A, Link AJ, Moses HL. (2010) Microdialysis combined with proteomics for protein identification in breast tumor microenvironment in vivo. Cancer Microenviron. 4(1): 61-71 PMID: 21505562, PMCID: PMC3047629.

Shaw A, Gipp J, Bushman W. (2009) Exploration of Shh and BMP paracrine signaling in a prostate cancer xenograft. Differentiation, 79 (1): 41-47 PMID: 19773112, PMCID: PMC2787832.

Shaw A, Gipp J, Bushman W. (2009) The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts. Oncogene, 28 (50): 4480-4490 PMID: 19784071, PMCID: PMC2795794.

Zhang J, Lipinski RJ, Gipp JJ, Shaw AK, Bushman W (2009) Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells. BMC Dev Biol, 9 (1): 50 PMID: 19811645, PMCID: PMC2767347.

Cook C, Vezina CM, Hicks SM, Shaw A, Yu M, Peterson RE, Bushman W (2007) Noggin is Required for Normal Lobe Patterning and Ductal Budding in the Mouse Prostate. Dev Biol, 312(1): 217-230 PMID: 18028901, PMCID: PMC2233847.

Bruxvoort KJ, Charbonneau HM, Giambernardi TA, Goolsby JC, Qian C-N, Zylstra CR, Robinson DR, Roy-Burman P, Shaw AK, Buckner-Berghuis BD, Sigler RE, Resau JH, Sullivan R, Bushman W, Williams BO (2007) Inactivation of Apc in the Mouse Prostate Causes Prostate Carcinoma. Cancer Res, 67(6): 2490-2496 PMID: 17363566.

Zhang J, Lipinski R, Shaw A, Gipp J, Bushman W (2007) Lack of Demonstrable Autocrine Hedgehog Signaling in Human Prostate Cancer Cell Lines. J Urol, 177: 1179-1185 PMID: 17296441.

Shaw A, Papadopoulos J, Johnson C, Bushman W (2006) Isolation and Characterization of an Immortalized Mouse Urogenital Sinus Mesenchyme Cell Line. Prostate, 66(13): 1347-1358 PMID: 16752376, PMCID: PMC2802279.

Fan L, Pepicelli CV, Dibble CC, Catbagan W, Zarycki JL, Laciak R, Gipp J, Shaw A, Lamm ML, Munoz A, Lipinski R, Thrasher JB, Bushman W.(2004) Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology 145(8):3961-3970 PMID: 15132968.

Gorny G, Shaw A, Oursler MJ (2004) IL-6, LIF, and TNF- Regulation of GM-CSF Inhibition of Osteoclastogenesis in vitro. Exp Cell Res 294: 149-158 PMID: 14980510.

Gingery A, Bradley E, Shaw A, Oursler MJ (2003) Phosphatidylinositol 3-Kinase Coordinately Activates the MEK/ERK and AKT/NFkB Pathways to Maintain Osteoclast Survival. J Cell Biochem 89(1): 165-179 PMID: 12682917.

Reviews:

Franco OE, Shaw AK, Strand DW, Hayward SW (2010) Cancer Associated Fibroblasts in Cancer Pathogenesis. Sem Cell Dev Biol 21(1): 33-39. Featured on the cover PMID: 19896548, PMCID: PMC2823834.

Shaw A, Attia S, Bushman W. (2008) UGSM-2: Prostate Stromal and Urogenital Sinus Mesenchymal Cell Lines for Investigations of Stromal-Epithelial Interactions. Differentiation, 76: 599-605 PMID: 18462435, PMCID: PMC3293184.

Shaw A, Bushman W (2007) Hedgehog Signaling in the Prostate. J Urol, 177: 832-838 PMID: 17296352.

Shaw A, Oursler M (1999) Paracrine Regulation of Osteoclast Activity in Metastatic Breast Cancer. Cancer Research Alert I(11):124-127.

Book Chapters:

Andrews MT, Tredrea MM, Shaw A (2004) Steroidogenesis and the HPA Axis During Hibernation: Differential Expression of the StAR Protein, in Life in the Cold (BM Barnes and HV Carey, eds) pg 407-415, Institute of Arctic Biology, Fairbanks, AK.

Teaching

Teaching Areas

Course Director:

  • Foundations of Medicine
  • Hormonal & Reproductive Medicine

Histology:

  • Foundations of Medicine
  • Skin/Musculoskeletal Medicine
  • Neurological Medicine
  • Immunology, Hematology, Oncology Medicine
  • Cardiovascular Medicine
  • Respiratory, Renal, Acid-Base Medicine
  • Gastrointestinal Medicine
  • Hormonal & Reproductive Medicine

Exam support:

  • Introduction to Biomedical Science