Shernan Holtan, MD

Associate Professor of Medicine, Division of Hematology, Oncology and Transplantation

Shernan Holtan

Contact Info

Mailing Address:
420 Delaware Street SE
MMC 480
Minneapolis, MN 55455

Administrative Assistant Name
Kristin Blomquist

Administrative Phone

Administrative Email

Administrative Fax Number

Associate Professor of Medicine, Division of Hematology, Oncology and Transplantation

Medical Director, Clinical Trials Office

Member, Masonic Cancer Center Executive Committee

Co-Chair, GVHD Cancer Center Translational Working Group

Director, Blood and Marrow Transplant Survivorship Clinic

Medical School, University of Nebraska, Lincoln, NE

Residency, Mayo Clinic, Rochester, MN

Fellowship, Mayo Clinic, Rochester, MN


Dr. Holtan is Associate Professor of Medicine in the Division of Hematology, Oncology, and Transplantation, where she serves as a hematologist focusing on allogeneic hematopoietic cell transplantation for malignant and non-malignant diseases, melanoma, and long-term survivorship. She also serves as a clinical/translational investigator focused on personalized immune monitoring, inflammation resolution, and the role of wound healing-associated growth factors in graft-versus-host disease. Dr. Holtan brings a strong track record of multidisciplinary research to the University of Minnesota. Since her hematology/oncology fellowship at Mayo Clinic, she has been studying the parallels of pregnancy and transplantation medicine in collaboration with physicians and scientists in obstetrics, maternal fetal medicine, immunology, and bioinformatics.


  • Immunotherapy
  • Allogeneic hematopoietic cell transplantation
  • Graft versus host disease
  • Long-term survivorship
  • Melanoma

Awards & Recognition

  • Board certified in internal medicine, oncology, and hematology
  • CIBMTR, member of Late Effects, Immunobiology, and GVHD working committees
  • OHSU Red Rose Award, 2013
  • Edward T. Creagan Award for Outstanding Contribution to Melanoma Research, 2011

Professional Associations

  • Co-Chair, BMT CTN 1703 Protocol Committee 2017-present
  • Member, BMT CTN Biomarkers Committee 2016-present
  • Member, BMT CTN 1501 Protocol Committee 2015-present
  • Elected Member, Midwest Melanoma Partnership Board of Directors 2015-present
  • Member, American Society for Blood and Marrow Transplantation 2008-present
  • Member, American Society for Hematology 2008-present
  • Member, American Society for Clinical Oncology 2007-present
  • Member, Minnesota Medical Association 2003-present


Research Summary/Interests

  • Personalized immune monitoring
  • Inflammation resolution in GVHD
  • Immunology of pregnancy
  • Immunology of Cancer

Research Funding Grants

  • National Marrow Donor Program Grant: Inflammation, Endothelial Damage, and Angiogenesis after Hematopoietic Cell Transplantation: A Biomarker Study of BMT CTN 0402
  • University of Minnesota Grant-in-Aid: Microbial, Graft, and Host Interactions in Hematopoietic Cell Transplantation
  • Medical Research Foundation, OHSU: Angiogenic hormones in post-hematopoietic cell transplantation immune responses
  • BIRCWH K12, OHSU: Sex-based differences in allogeneic immune responses
  • Women’s Health Research Program, Mayo Clinic: Fetomaternal tolerance: Implications for development of novel immunologic cancer therapies