Jill Siegfried, PhD

Professor & Head, Department of Pharmacology

Jill Siegfried

Contact Info

jsiegfri@umn.edu

Office Phone 612-624-2584

Office Address:
3-112 Nils Hasselmo Hall
312 Church St SE'
Minneapolis, MN 55455

3-130 Cancer and Cardiovascular Research Building
2231 6th St SE
Minneapolis, MN 55455

Lab Address:
3-230 Cancer and Cardiovascular Research Building
2231 6th St SE
Minneapolis, MN 55455

Administrative Assistant Name
Hannah Salen

Administrative Phone
612-625-0458

Administrative Email
salen011@umn.edu

Administrative Fax Number
612-625-8408

Professor & Head, Department of Pharmacology

Frederick and Alice Stark Endowed Chair, Department of Pharmacology

Associate Director, Translational Research, Masonic Cancer Center (MCC)


Postdoctoral Fellow, University of North Carolina, Chapel Hill

PhD, Yale University

Summary

Dr. Jill Siegfried received her Ph. D. in Pharmacology from Yale University and did her post-doctoral fellowship at the University of North Carolina in Chapel Hill at the Lineberger Cancer Center. She works in the field of lung cancer biology and experimental therapeutics, focusing on targeting growth factors and hormone signaling that control lung cancer cell proliferation to treat lung cancer, and how immunotherapy can be enhanced by targeted therapy. She was the Principal Investigator of the SPORE in Lung Cancer grant at the University of Pittsburg from 2000-2013. In this capacity, she oversaw translational research carried out by the SPORE research team of basic, population, and clinical scientists. Dr. Siegfried has been Professor and Head of Pharmacology at the University of Minnesota and Associate Director for Translation at the Masonic Cancer Center since 2013, and in these roles is active in mentoring students, post-doctoral fellows, and faculty, as well as promoting research in experimental therapeutics and cancer prevention. She is also active in promoting diversity and gender equity in the health sciences.

Expertise

Combination therapy to generate synergy, interaction between immunotherapy, targeted therapy and signal transduction

Awards & Recognition

University of Minnesota

Center for Women in Medicine and Science Leadership Award (2019)

Frederick & Alice Stark Endowed Chair in Pharmacology (2013)

External Sources

Inaugural Chairholder, UPMC Endowed Chair for Lung Cancer Research (2009)

Girls Scouts of Southwestern Pennsylvania Woman of Distinction in the Sciences (2003)

University of Pittsburgh Cancer Institute Scientific Leadership Award (2002)

Fellow, Executive Leadership in Academic Medicine Program for Women (2001-2002)

Alton Ochsner Award Relating Smoking and Health (2000)

Charlotte Geyer Foundation Award (1994)

Wendy Will Case Cancer Fund Award (1991)

American Cancer Society Junior Faculty Research Award(1989 – 1992)

National Research Service Award, Individual Post-Doctoral Fellowship (1981 – 1982)

Graduated with Honors, Wellesley College (1976)

Wellesley Scholar, with Distinction (1976)

Phi Beta Kappa (1975)

Slater Scholarship for International Study (1975)

Professional Associations

American Society of Medical School Pharmacology Chairs

Free to Breathe (formerly National Lung Cancer Partnership)

Society for Executive Leadership in Academic Medicine

American Society for Pharmacology and Experimental Therapeutics

International Association for the Study of Lung Cancer

American Association for Cancer Research

American Association for Cell Biology

American Association for the Advancement of Science

Research

Research Summary/Interests

Research in the Siegfried laboratory focuses on the effects of growth factor, hormones and cytokines on control of tumor growth, their role in risk for cancer, and their signaling pathways. Growth factors and their receptors currently under investigation include estrogen, progesterone, the epidermal growth factor family and the STAT3 signaling system Dr. Siegfried’s laboratory is interested in the modulation of gene expression by these ligands in malignant lung cells, the relationship between exposure to tobacco smoke and production of hormones and growth factors by cells derived from the human lung, and the role of steroid hormones in influencing tumor growth and response to immunotherapy. These pathways are also being targeted for chemoprevention. Both cell culture and animal models are used to examine how these hormones and growth factors interact in the development and growth of lung cancer.

These studies are directed toward development of new strategies for lung cancer prevention and treatment through increased knowledge of growth regulatory processes in lung cancer cells.

Publications