Research Programs: Genetic Mechanisms of Cancer
Associate Professor and Co-Director, Division of Basic and Translational Research, Department of Surgery

yamam016@umn.edu
612-624-9131 — office
612-624-9114 — lab
Preferred method of contact: e-mail

Dr. Yamamoto received his M.D. from Osaka University School of Medicine in 1988 and his Ph.D. from Osaka University School of Medicine in 1997. In 1999 he conducted a postdoctoral fellowship at the University of Alabama in Birmingham. He remained at the University of Alabama and his most recent appointments there were Resaerch Associate Professor in the Division of Human Gene Therapy, Department of Surgery, Medicine, and Pathology and member of the Comprehensive Cancer Center. He joined the faculty of the Department of Surgery at the Univerity of Minnesota in August 2006.

Research Interests

• GI-cancer translational research
• Gene therapy of cancer
• Adenoviral vectors

Selected Publications

Le LP, Le HN, Dmitriev IP, Davydova JG, Gavrikova T, Yamamoto S, Curiel DT, Yamamoto M. Dynamic monitoring of oncolytic zdenovirus in vivo by genetic capsid labeling. J Natl Cancer Inst. 2006;98:203-214.

Ono HA, Le LP, Davydova JG, Gavrikova T, Yamamoto M. Non-invasive Visualization of Adenovirus Replication with a Fluorescent Reporter in the E3 Region. Cancer Res. 2005;65:10154-10158.

Yamamoto M, Nishimoto N, Davydova J, Kishimoto T, Curiel DT. Suppressor of cytokine signaling-1 (SOCS-1) expression by infectivity enhanced adenoviral vector inhibits IL-6 dependent proliferation of multiple myeloma cells. Cancer Gene Ther. 2006;13:194-202.

Tekant Y, Davydova J, Ramirez PJ, Curiel DT, Vickers SM, Yamamoto M. Oncolytic adenoviral therapy in gallbladder carcinoma. Surgery 2005:137:527-535.

Davydova J, Le LP, Gavrokova T, Wang M, Krasnykh V, Yamamoto M. Infectivity-enhanced cyclooxygenase-2-based conditionally replicative adenoviruses for esophageal adenocarcinoma. Cancer Res. 2004:64:4319-4327.

Yamamoto M, Davydova J, Wang M, Siegal GP, Krasnykh V, Vickers SM and Curiel DT. Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology 2003;125:1203-1218.

Book Chapter

Masato Yamamoto, David T. Curiel. Gene Therapy of Pancreatic Cancer In: Pancreatic Cancer. Editors: Daniel D. Von Hoff, Douglas B. Evans, Ralph H. Hruban. Jones and Bartlett Publishers. 2005