Research Program: Carcinogenesis and Chemoprevention Research Program
Professor, Department of Pharmaceutics

wiedm001@umn.edu
612-624-5457 — office
Preferred method of contact: e-mail

Dr. Wiedmann received his Ph.D. in pharmaceutics for the University of Wisconsin in 1985. Following postdoctoral research in the Department of Chemistry and Biophysics at the University of Virginia in Charlottesville, he joined the faculty in the Department of Pharmaceutics at the University of Minnesota in 1987.

Research Interests

Drug delivery with specific interests in the development of aerosol technology for the respiratory delivery of chemopreventive agents to rodents. Analysis of the influence of lung lining fluids on the distribution of drugs/carcinogens in the lung.

Selected Publications

Pithavala YK, Odishaw JL, Han S, Wiedmann TS, and Zimmerman CL. Retinoid absorption from simple and mixed micelles in the rat intestine. J Pharm Sci. 1995;84:1360-1365.

Li C-Y, Zimmerman C, Wiedmann TS. Solubilization of retinoids by bile salt/phospholipid aggregates. Pharm Res. 1996;13:907-913.

Wiedmann TS, DeCastro L, Wood RW. Nebulization of nanocrystals. Production of a respirable solid-in-liquid-in-air colloidal dispersion. Pharm Res. 1997;14:112-116.

Wattenberg L, Wiedmann TS, Estensen RD, Zimmerman CL, Steele VE, Kelloff GJ. Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res. 1997;57:5489-5492.

Han C, Wiedmann TS. Spectral properties and ion dissociation behavior on retinoids. I. Aqueous solutions. Int J Pharm. 1998;172:241-253.

Han C, Zimmerman CL, Wiedmann TS. Spectral properties and ion dissociation behavior on retinoids. II. Bile salt solutions. Int J Pharm. 1998;172:229-240.

Wattenberg L, Wiedmann TS, Estensen RD, Zimmerman CL, Steele VE, Kelloff GJ. Chemoprevention of pulmonary carcinogenesis in female A/J mice by brief exposure to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. Carcinogenesis 2000;21:179-182.

Wiedmann TS, Bhatia R, Wattenberg LW. Drug solubilization in lung surfactant. J Control Rel. 2000;65:43-47.

Zimmerman CL, Han S, Wiedmann TS. The absorption of retinoic acids from the gastrointestinal tract is dependent upon chemical structure. Cancer Chemother Pharmacol. 2001;47:27-33.

Pham S, Wiedmann TS. Note: Dissolution of aerosol particles of budesonide in Survanta, a model lung surfactant. J Pharm Sci. 2001;90:98-104.

Wiedmann TS, Ravichandran A . Ultrasonic nebulization system for respiratory drug delivery. Pharm Dev Tech.2001;6:83-90.

Estensen RD, Jordan MM, Wiedmann TS, Galbraith AR, Steele VE, Wattenberg LW. Effect of chemopreventive agents on separate stages of progression of benzo[a]pyrene induced lung tumors in A/J mice. Carcinogenesis 2004;25:197-201.

Wattenberg LW, Wiedmann TS, Estensen RD. Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil. Cancer Res. 2004;64:2347-2349.

Liao X, Liang W, Wiedmann TS, Wattenberg L, Dahl A. Lung distribution of the chemopreventive agent difluoromethylornithine (DFMO) following oral and inhalation delivery. Exp Lung Res 2004;30:755-769.

Wiedmann TS, Hitzman CJ. Reflux drying of aerosols. J Aerosol Med. 2004;17:344-353.

Hitzman CJ, Wiedmann TS, Dai H, Elmquist WF. Measurement of drug release from microcarriers by microdialysis. J Pharm Sci. 2005;94: 1456-1466.

Hitzman CJ, Elmquist WF, Wattenberg LW, Wiedmann TS. Development of a respirable, sustained release microcarrier for 5-fluorouracil I: In vitro assessment of liposomes, microspheres, and lipid coated nanoparticles. J Pharm Sci. 2006;95:1114-26.

Hitzman CJ, Elmquist WF, Wiedmann TS. Development of a respirable, sustained release microcarrier for 5-fluorouracil II: In vitro and in vivo optimization of lipid coated nanoparticles. J Pharm Sci. 2006;95:1127-43.

Yan Y, Cook J, McQuillan J, Zhang G, Hitzman CJ, Wang Y, Wiedmann TS, You M. Chemopreventive effect of aerosolized polyphenon E against lung tumorigenesis in A/J mice. Neoplasia 2007;9:401-405.