Program Co-leader: Transplant Biology and Therapy Research Program
Professor, Department of Medicine
Director, Adult Blood and Marrow Transplant Program

weisd001@umn.edu
612-624-3101 — office
Preferred method of contact: e-mail

Dr. Weisdorf's clinical profile
(University of Minnesota Physicians Web site)

Dr. Weisdorf received his M.D. from the Chicago Medical School and completed an internal medicine residency at Michael Reese Hospital in Chicago. He completed a Hematology Oncology fellowship at the University of Minnesota. He now serves as director of the Adult Blood and Marrow Transplant Program at the University of Minnesota; co-leader of the Transplant Biology and Therapy Research Program; scientific director of the National Marrow Donor Program; and senior research advisor for the Center for International Blood and Marrow Transplant Research.

Research Interests

• Applications, complications and long term outcomes of hematopoietic stem cell transplantation.
• Prevention and management of graft vs. host disease immunotherapy of malignancies

Selected Publications

Weisdorf D, Bishop M, Dharan B, Bolwell B, Cahn JY, Cairo M, Giralt S, Klein J, Lazarus H, Litzow M, Marks D, McCarthy P, Miller C, Milone G, Russell J, Schultz KR, Sierra J, Wiernik P, Keating A, Loberiza F, Kollman C, Horowitz M: Autologous versus allogeneic unrelated donor transplantation for acute lymphoblastic leukemia: comparative toxicity and outcomes. Biol Blood Marrow Transplant, 8:213-220, 2002.

Weisdorf DJ, Anasetti C, Antin JH, Kernan NA, Kollman C, Snyder D, Petersdorf E, Nelson G, McGlave P: Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated versus matched sibling donor transplantation. Blood, 99(6):1971-1977, 2002.

Metayer C, Curtis RE, Vose J, Sobocinski KA, Horowitz MM, Bhatia S, Fay JW, Freytes CO, Goldstein SC, Herzig RH, Keating A, Miller CB, Nevill TJ, Pecora AL, Rizzo JD, Williams SF, Li CY, Travis LB, Weisdorf DJ: Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multi-center case-control study. Blood, 1:101(5):2015-223, 2003.

Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE: Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning. Blood, 102(5):1915-1999, 2003.

Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovoch A, Horowitz M, Hurley C, Kollman C, Anasetti C, Noreen H, Begovich A, Hildebrand W, Petersdorf E, Schmeckpeper B, Setterholm M, Trachtenberg E, Williams T, Yunis E, Weisdorf D: Impact of HLA class I and class II high resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplant outcome. Blood, 104(7):1923-30, 2004

Blazar BR, Weisdorf DJ, Defor T, Goldman A, Braun T, Silver S, Ferrara JL. Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). Blood, 108(9)3216-3222, 2006.

Miller JS, Cooley S, Parham P, Farag SS, Verneris MR, McQueen KL, Guethlein LA, Trachtenberg EA, Haagenson M, Horowitz MM, Klein JP, Weisdorf DJ: Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT. Blood, 109:5058-5061, 2007.

Tallman MS, Dewald GW, Gandham S, Logan BR, Keating A, Lazarus HM, Litzow MR, Mehta J, Pedersen T, Perez WA, Rowe JM, Wetzler M, Weisdorf DJ: Impact of cytogenetics on outcome of matched unrelated donor hematopoietic stem cell transplantation for acute myeloid leukemia in first or second complete remission. Blood, 110(1)409-417, 2007.

Giralt S, Logan B, Rizzo D, Zhang MJ, Ballen K, Emmanouilides C, Nath R, Parker P, Porter D, Sandmaier B, Waller EK, Barker J, Pavletic S, Weisdorf D. Reduced-intensity conditioning for unrelated donor progenitor cell transplantation: Long-term follow-up of the first 258 reported to the National Marrow Donor Program. Biol Blood Marrow Transplant, 13(7)844-852, 2007.

Walker CM, van Burik JH, DeFor T, Weisdorf DJ. Cytomegalovirus infection after allogeneic transplantation: Comparison of cord blood with peripheral blood and marrow graft sources. Biol Blood Marrow Transplant (In Press)

Miller JS, Weisdorf DJ, Burns LJ, Slungaard A, Wagner JE, Verneris MR, Cooley S, Wagner JE, Fautsch SK, Nicklow R, Defor T, Blazar, BR. Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone. Blood (In Press)