Research Program: Genetic Mechanisms of Cancer
Assistant Professor, Department of Laboratory Medicine and Pathology

subree@umn.edu
612-626-4330 — office
612-626-2735 — lab
Preferred method of contact: e-mail

Dr. Subramanian received his Ph.D. in molecular and cell biology in 2003 from the Center for Cellular and Molecular Biology, Jawaharlal Nehru University, India, and completed his post-doctoral fellowship at Stanford University, Stanford, California. He joined the faculty of the Department of Laboratory Medicine and Pathology at the University of Minnesota in 2007 and studies the molecular mechanisms of tumor development and progression.

Research Interests

MicroRNA mediated gene regulation in human sarcomas; gene expression profiles—developing novel diagnostic markers and identification of therapeutic targets in sarcomas and other cancers.

For more information, see Dr. Subramanian's Lab Web site:
http://www.tc.umn.edu/˜subree/

Selected Publications

Subramanian S, Lui WO, Lee CH, Espinosa E, Nielsen T, Heinrich M, Corless C, Fire A, and van de Rijn M. MicroRNA expression signature of human soft tissue tumors Oncogene 2008 27:2015-2016

Lubieniecka JM, de Bruijn D, Su L,van Dijk A, Subramanian S, van de Rijn M, Poulin N, van Kessel A,Nielsen TO.Histone deacetylase inhibitors reverse SS18-SSX mediated polycomb silencing of the tumor suppressor EGR1 in synovial sarcoma. Cancer Res 2008 (in press)

Lee C, Espinosa I, Jensen K, Subramanian S, Zhu S, Varma S, Montgomery K, Nielsen TO, van de Rijn M and West R. Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone Modern Pathology 2008 (in press)

Lee C, Espinosa I, Vrijaldenhoven S, Subramanian S, Montgomery K, Zhu S, Poulin N, Nielsen T, West R, Gilks B, van de Rijn M. Prognostic significance of macrophage marker in leiomyosarcomas. Clin Caner Res 2008 14; 1423-1430

Espinosa I, Lee C, Kim M, Rouse B, Subramanian S, Montgomery K, Corless CL, Heinrich MC, Smith KS, et al. A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Path 2007 32; 210-218

Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, Downs-Kelly E, Corless CL, Rubin BP, van de Rijn M, Ladanyi M, and Nielsen TO. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies Am J Surg Path 2007 31: 240-246

West RB, Rubin BP, Miller M, Subramanian S, Kaygusuz G, Montgomery K, Luca AD, Gilks B, Nielsen TO, Huntsman D and van de Rijn M. CSF1-COL6A3 gene fusion is present in a minority of tumor cells in tenosynovial giant cell tumor and pigment villonodular synovitis Proc Natl Acad Sci  USA 2006 103:690-695

Subramanian S, West RB, Marinelli RJ, Nielsen TO, Rubin BP, Goldblum JR, Patel RM, Zhu S, Montgomery K, Ng TL, Corless CL, Heinrich MC, and van de Rijn M. Gene Expression Profile of Extraskeletal Myxoid Chondrosarcoma J Pathol 2005 206:433-444

West RB, Nuyten DSA, Subramanian S, Corless CL, Rubin BP, Montgomery K, Zhu SX, Nielsen TO, Patel R, Goldblum JR, Brown PO, van de Vijver M, van de Rijn M. Stromal Expression Signatures Predict Outcome in Breast Carcinoma PLoS Biol 2005 3:3187

Subramanian S, West RB, Corless CL, Ou W, Rubin BP, Chu K, Leung SY, Yuen ST, Zhu S, Hernandez-Boussard T, Montgomery KD, Nielsen TO, Patel RM, Goldblum JR, Heinrich MC,  Fletcher JA and van de Rijn M. Gastrointestinal Stromal Tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles Oncogene 2004 23: 7780-779

West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery KD, Zhu S, Ball CA, Nielsen TO, Patel R, Goldblum JR, Brown PO, Heinrich MC and van de Rijn M. The Novel Marker, DOG1, is expressed ubiquitously in Gastrointestinal Stromal Tumors irrespective of KIT or PDGFRA mutation status Am J Pathol 2004 165: 107-113

Subramanian S, Mishra RK and Singh L Genome-wide analysis of microsatellite repeats in human: Abundance and their density in specific genomic regions Genome Biol. 2004 4:R13

Subramanian S, Mishra RK and Singh L. Genome-wide analysis of Bkm sequences (GATA repeats): Predominant association with sex chromosomes and potential role in higher order chromatin organization and function  Bioinformatics 2003 19: 681-685

Subramanian S, Madugula VM, George R, Mishra RK, Pandit MW, Chanderashekar S Kumar and Singh L. Triplet Repeats Analysis in Human Genome: Abundance, Distribution and Association with Genes and other Genomic Regions Bioinformatics 2003 19: 549-552

Subramanian S, Madugula VM, George R Satish Kumar C, Pandit MW and Singh L. SSRD: A simple sequence repeat database for human genome Comparative and Functional Genomic 2003 4: 342-345