Research Program: Women's Cancer
Professor Emeritus, Department of Therapeutic Radiology
Director, Radiation Biology and Molecular Cancer Therapeutics, Department of Therapeutic Radiology

songx001@umn.edu
612-626-6852 — office
612-626-6090 — lab
Preferred method of contact: phone or e-mail (secretary: Karina Lawrence at 612-66-2631 or lawre012@umn.edu)

Dr. Song received a B.S. in Chemistry from Seoul National University in 1957 and a M.S. in Biochemistry from Korea University in 1959. He matriculated to the University of Iowa where he received a Ph.D. in Radiation Biology in 1964. He joined the faculty of the Department of Therapeutic Radiology-Radiation Oncology at the University of Minnesota in 1970.

Research Interests

• Role of blood flow, pO2 and pH in tumor treatment
• Effect of radiation and hyperthermia on tumor physiology, e.g. blood flow, pH, pO2 and glucose metabolism
• Chemical radiosensitization and radioprotection
• Molecular mechanism of apoptosis caused by radiation, drugs, and heat shock

Selected Publications

Choi EK, Roberts KP, Griffin RJ, Han T, Park HJ, Song CW, Park HJ. Effect of pH on radiation-induced p53 expression. Int J Radiat Oncol Biol Phys. 2004;60:1264-1271.

Park HJ, Choi EK, Choi J, Ahn KJ, Kim EJ, Ji IM, Kook YH, Ahn SD, Williams B, Griffin R, Boothman DA, Lee CK, Song CW. Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone. Clin Cancer Res. 2005;11:8866-8871.

Park HJ, Ahn KJ, Ahn SD, Choi E, Lee SW, Williams B, Kim EJ, Griffin R, Bey EA, Bornmann WG, Gao J, Park HJ, Boothman DA, Song CW. Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation. Int J Radiat Oncol Biol Phys. 2005;61:212-219.

Dings RP, Williams BW, Song CW, Griffioen AW, Mayo KH, Griffin RJ. Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells. Int J Cancer. 2005;115:312-319.

Griffin RJ, Williams BW, Park HJ, Song CW. Preferential action of arsenic trioxide in solid-tumor microenvironment enhances radiation therapy. Int J Radiat Oncol Biol Phys. 2005;61:1516-1522.

Griffin RJ, Ogawa A, Williams BW, Song CW. Hyperthermic enhancement of tumor radiosensitization strategies. Immunol Invest. 2005;34:343-359.

Song CW, Park HJ, Lee CK, Griffin R. Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. Int J Hyperthermia 2005;21:761-767. Review.

Visaria RK, Griffin RJ, Williams BW, Ebbini ES, Paciotti GF, Song CW, Bischof JC. Enhancement of tumor thermal therapy using gold nanoparticle-assisted tumor necrosis factor-alpha delivery. Mol Cancer Ther. 2006;5:1014-1020.

Suzuki M, Amano M, Choi J, Park HJ, Williams BW, Ono K, Song CW. Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro. Radiat Res. 2006;165:525-531.

Choi EK, Ji IM, Lee SR, Kook YH, Griffin RJ, Lim BU, Kim JS, Lee DS, Song CW, Park HJ. Radiosensitization of tumor cells by modulation of ATM kinase. Int J Radiat Biol. 2006;82:277-283.