Research Program: Women's Cancer
Assistant Professor, Department of Physiology; University of Minnesota, Duluth

trosehel@d.umn.edu
218-726-6621, office

Research Interests

Uses transgenic mouse models to study the genetic and hormonal influences of breast cancer. Currently is investigating the molecular and cellular targets of tamoxifen chemoprevention.

Selected Publications

Zhang H, Skildum A. Stromquist E, Rose-Hellekant TA, Chang LC. Bioactive Polybrominated Diphenyl Ethers from the Marine Sponge Dysidea sp. 10. Journal of Natural Products 2008 71(2):262-4.

Rose-Hellekant, T.A., Schroeder, M., Brockman, J.L., Zhdankin, O., Bolstad, R., Chen, K.S., Gould, M., Schuler, L.A. and Sandgren, E.P. (2007). Estrogen receptor positive mammary tumorigenesis in TGFalpha transgenic mice progresses with progesterone receptor loss. Oncogene. 2007 Aug 9;26(36):5238-46.

Rose-Hellekant, T.A., Wentworth, K.M., Nikolai, S., Kundel, D.W. and Sandgren, E.P. (2006) Mammary carcinogenesis is preceded by altered epithelial cell turnover in TGFalpha and c-myc transgenic mice. Am. J. Path.169(5):1821-32

Arendt, L.M., Rose-Hellekant, T.A., Sandgren, E.P. and Schuler, L.A. (2006) Prolactin potentiates transforming growth factor a induction of mammary neoplasia in transgenic mice. Am. J. Pathol. 168:1365-1374.

Rose-Hellekant TA, Arendt LM, Schroeder MD, Gilchrist K, Sandgren EP, Schuler LA. Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice. Oncogene. 2003 Jul 24; 22(30):4664-74.

Rose-Hellekant TA, Gilchrist K, Sandgren EP. Strain background alters mammary gland lesion phenotype in transforming growth factor-alpha transgenic mice. Am J Pathol. 2002 Oct; 161(4):1439-47.

Schroeder MD, Rose-Hellekant TA, Sandgren EP, Schuler LA. Dysregulation of mammary Stats 1,3 and 5 and PRL receptors by overexpression of TGFalpha. Mol Cell Endocrinol. 2001 Apr 25; 175(1-2):173-83.

Rose-Hellekant TA, Sandgren EP. Transforming growth factor alpha- and c-myc-induced mammary carcinogenesis in transgenic mice. Oncogene. 2000 Feb 21; 19(8):1092-6.

Rose-Hellekant TA, Libersky-Williamson EA, Bavister BD. Energy substrates and amino acids provided during in vitro maturation of bovine oocytes alter acquisition of developmental competence. Zygote. 1998 Nov; 6(4):285-94.