Research Program: Prevention & Etiology
Professor, Department of Medicine

pentel@umn.edu
612-347-6426, office

Research Interests

Medications development for the treatment of tobacco addiction, using pharmacokinetic and behavioral animal models of nicotine addiction to study mechanisms and interventions.

Selected Publications

Roiko SA, Harris AC, Keyler DE, Lesage MG, Zhang Y, Pentel PR. Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats. J Pharmacol Exp Ther. 2008 Feb 27; [Epub ahead of print]

Harris AC, Burroughs D, Pentel PR, LeSage MG. Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction. Exp Clin Psychopharmacol. 2008 Feb;16(1):86-97.

Pentel PR, Dufek MB, Roiko SA, Lesage MG, Keyler DE. Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats. J Pharmacol Exp Ther. 2006 May;317(2):660-6. Epub 2006 Jan 11.

Lesage MG, Keyler DE, Hieda Y, Collins G, Burroughs D, Le C, Pentel PR. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology (Berl). 2005 Jul 1,1-8.

Keyler DE, Dufek MB, Calvin AD, Bramwell TJ, LeSage MG, Raphael DE, Ross CA, Le CT, Pentel PR. Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: time course and influence of nicotine dosing regimen. Biochem Pharmacol. 2005 May 1; 69(9):1385-95.

LeSage MG, Burroughs D, Dufek M, Keyler DE, Pentel PR. Reinstatement of nicotine self-administration in rats by presentation of nicotine-paired stimuli, but not nicotine priming. Pharmacol Biochem Behav. 2004 Nov; 79(3):507-13.

LeSage MG, Keyler DE, Collins G, Pentel PR. Effects of continuous nicotine infusion on nicotine self-administration in rats: Relationship between continuously infused and self-administered nicotine doses and serum concentrations. Psychopharmacol 2003;170:278-286.

Hatsukami DE, Rennard S, Jorenby D, Fiore M, Koopmeiners J, deVos A, Horwith G, Pentel PR. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther. 2005 Nov;78(5):456-67.