Research Programs: Immunology
Professor, Department of Neurosurgery

lowwalt@umn.edu
612-626-9200 — office
Preferred method of contact: e-mail

Dr. Low received his Ph.D. degree from the University of Michigan, and completed his fellowship training at the Cambridge University in England. He was on the faculty at the Indiana University School of Medicine prior to taking his current position in the Department of Neurosurgery here at the University of Minnesota.

Research Interests

Dr. Low's research is focused on the development of therapies for the treatment of brain tumors. He current work is directed at the development of cancer vaccines using brain tumor stem cells and dendritic cells for the treatment of pediatric medulloblastomas and glioblastoma multiforme.

Selected Publications

Wu AH, J Xiao, L Anker, WA Hall, DS Gregerson, WK Cavenee, W Chen, and WC Low, Identification of EGFRvIII-derived epitopes restricted by HLA A0201 for dendritic cell based immunotherapy of gliomas, J Neurooncol. 2006;76:23-30.

Ohlfest JR, Demorest ZL, Motooka Y, Vengco I, Oh S, Chen E, Scappaticci FA, Saplis RJ, Ekker SC, Low WC, Freese AB, and Largaespada DA. Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the Sleeping Beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Mol Ther. 2005;12:778-788.

Jean WC, SR Spellman, MA Wallenfriedman, WA Hall, and WC Low. Granulocyte-macrophage colony-stimulating factor and interleukin-based immunotherapy against rat intracranial 9L glioma. J Neurooncol. 2004;66:39-49.

Wu AH and WC Low, Molecular cloning and Identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter. Neuro-Oncology 2003;5:179-187.

Wu AH and WC Low, Molecular cloning of the rat IL-13 alpha 2 receptor cDNA and its expression in rat tissues, J Neurooncol. 2002;59:99-105.

Ni, H.T., S.R. Spellman, W.C. Jean, W.A. Hall, and W.C. Low, Immunization with dendritic cells pulsed with tumor extractice bearing intracranial gliomas, J Neurooncol. 2001;51:1-9.