Research Program: Transplant Biology & Therapy
Distinguished Professor, Department of Biostatistics, School of Public Health
Director, Biostatistics and Informatics Shared Resource

chap@umn.edu
612-624-9963 — office
Preferred method of contact: e-mail

Dr. Le received a B.S. in mechanical engineering from California State University, Fresno, and a Ph.D. in statistics from the University of New Mexico. He joined the faculty of the University of Minnesota in 1978. Dr. Le Has published nine books and over 170 research papers in various journals.

Research Interests

Dr. Le's research interests are data-driven and include epidemiological methods, cross-over designs, survival analysis, ordered alternatives, ROC curves, and methods for the analysis of in vitro experiments—especially chemo-combination therapy. His collaborations have focused on analyses of survival and categorical data. Currently, his major concentrations are in the areas of cancers and tobacco research.

Selected Publications

Le C.T. and P.M. Grambsch. Design and Analysis of In Vitro Experiments for Combination Chemotherapy. J of Biopharmaceutical Statistics 15: 179-186, 2005.

Le C.T. A Solution for the most basic Optimization Problem associated with an ROC Curve. Statistical Methods in Medical Research 15: 571-584, 2006.

Church T.R., Anderson K.E., Caporaso N.E., Geisser M.S., Le C.T., Zhang Y., Benoit A.R., Carmella S.G., Hecht S.S. A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiology, Biomarkers & Prevention 18: 260-266, 2009.

Cooley S., Trachtenberg E., Bergemann T.L., Saeteurn K, Klein J, Le C.T., Marsh S.G., Guethlein L.A., Parham P., Miller J.S., Weisdorf D.J. Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia. Blood 113:726-32, 2009.