Research Program: Transplant Biology and Therapy
Associate Professor, Department of Experimental and Clinical Pharmacology

jacob117@umn.edu
612-624-6118, office
Preferred method of contact: e-mail

Dr. Jacobson received her Pharm.D. in 1986 from the University of Nebraska and completed her general residency in 1987 at the Veteran's Administration Medical Center and University of Michigan in Ann Arbor. She also completed a specialty residency in infectious disease in 1988 at the University of Michigan.

Research Interests

Clinical pharmacology of antineoplastic agents and immune modulators.

Selected Publications

Ng J, Rogosheske J, Barker, J, Weisdorf, D, Jacobson PA. A Limited Sampling Model for Estimation of Total and Unbound Mycophenolic Acid (MPA) Area Under the Curve (AUC) in Hematopoietic Cell Transplantation (HCT). Ther Drug Monit. 2006;Jun;28(3):394-401.

Jacobson PA, Green K, Rogosheske J, Brunstein B, Ebeling B, Defor T, McGlave P, Weisdorf D. Bioavailability of Mycophenolate in Patients Undergoing Nonmyeloablative Hematopoietic Cell Transplantation. J Clinical Pharmacology. 2007;47(1):6-12.

Huang J, Jacobson PA, Brundage R. Prediction of Unbound Mycophenolic Acid Concentrations in Patients After Hematopoietic Cell Transplantation. Ther Drug Monit. 2007;29:385-390.

Jacobson PA, Rydholm N, Huang J, Baker KS, Verneris M. High Unbound Mycophenolic Acid Concentrations in an Infant on Peritoneal Dialysis Following Hematopoietic Cell Transplant (HCT). Bone Marrow Transplantation, 2007:40;911-912.

Kirstein M, Root S, Moore M, Wieman K, Williams B, Jacobson P, Marker P, Tuttle T. Exposure-Response Relationships for Oxaliplatin Treated Colon Cancer Cells, Anti-Cancer Drugs. 2008:19(1):37-44.

Jacobson PA, Huang J, Rydholm N, Tran M, DeFor T, Tolar J, Orchard P. Higher Mycophenolate Dose Requirement in Children Undergoing Hematopoietic Cell Transplantation (HCT). J Clinical Pharmacology. 2008:48;485-494.

Johnson L, Orchard P, Baker KS, Brundage R, Cao Q, Wang X, Langer E, Farag-El Maasah S, Ross JA, Remmel RP, Jacobson PA. Glutathione-s-transferase A1 Genetic Variants Reduce Busulfan Clearance in Children Undergoing Hematopoietic Cell Transplantation. J Clin Pharmacology. 2008. 48 1052-1062.

Ibrahim R, Abidi M, Ayash L, Cronin S, Mulawa J, Jacobson PA, Smith D, Uberti J, Edwards D. Effect of aprepitant on intravenous tacrolimus disposition in reduced intensity hematopoietic cell transplantation. J Oncol Pharm Practice. 2008;14:113-121.

Johnson L, Oetting Wm, Basu S, Prausa S, Matas A, Jacobson PA. Pharmacogenetic Effect of the UGT Polymorphisms on Mycophenolate is Modified by Calcineurin Inhibitors. Eur J Clin Pharmacology. 2008;64; 1047-56

Jacobson PA, Farag El-Massah S, Rogosheske J, Kerr A, Boyle-Long J, DeFor T, Jennisen C, Brunstein C, Wagner J, Tomblyn M, Weisdorf D. Comparison of Two Mycophenolate Mofetil Dosing Regimens Following Hematopoietic Cell Transplantation. Bone Marrow Transplantation, 2009; 1-8.