Research Program: Women's Cancer
Associate Professor, Department of Therapeutic Radiology
Faculty Member, Biomedical Engineering, Biophysical Sciences and Medical Physics

huixx019@umn.edu
612-626-4484 — office
Preferred method of contact: e-mail

Dr. Hui received his Ph.D. in experimental nuclear physics in 1999 at the University of Calcutta and Nuclear Science Centre in New Delhi, India. He completed postdoctoral fellowships at the University of Purdue, West Lafayette, Ind. (Department of Physics); the Applied Physics Institute, Western Kentucky University, Bowling Green, Ky.; and Racah Institute of Physics, Hebrew University, Israel. He was a clinical physics resident in the Department of Human Oncology, University of Wisconsin, Madison, from 2001 to 2003. Dr. Hui came to the University of Minnesota in 2004; he is now an associate professor in the Department of Therapeutic Radiology and a faculty member of Biomedical Engineering, Biophysical Sciences and Medical Physics.

Research Interests

Bone Biomarker Research

1. Metabolic bone disease
   • Development of 41Ca tracer for early detection of bone remodeling
   • Development of quantitative computed tomography (QCT) (imaging biomarker)
2. Animal model
   • Osteoporosis model
3. Clinical applications of bone biomarker research
   • Cancer survivors' quality of life (breast cancer survivors, transplant survivors)
   • Osteoporosis

Targeted Therapy

1. Development of total marrow and lymphoid irradiation (TMI/TMLI)
   • Anatomical image-guided conformal-targeted radiation and conformal avoidance of critical organs
   • Real-time intra-fraction body motion tracking and its impact on targeted radiation therapy
2. Animal model
   • Radiation-induced changes in the bone and marrow compartments in mice
3. Clinical applications of targeted therapy research
   • High-risk and relapsed patients with hematological malignancies (leukemia, lymphoma); and
   • solid tumors (Ewing sarcoma, neuroblastoma)

Selected Publications

Balog J, Mackie TR, Pearson D, Hui SK, Paliwal B, Jeraj R. Benchmarking beam alignment for a clinical helical tomotherapy device. Medical Physics 2003; 30: 1118-1127.

Welsh JS, Hui SK, Lock M, Limmer J, Barton D, Thurman SA. Breast edema during radiotherapy can result in underdosing. The Cancer Journal. 2003; 9, 6: 507-8.

Mackie TR, Olivera GH, Kapatoes JM, Ruchala KJ, Balog JP, Tome WA, Hui S, Kissick M, Wu C, Jeraj R, Reckwerdt PJ, Harari P, Ritter M, Forrest L, Welsh J, Mehta MP. Helical Tomotherapy in Intensity-Modulated Radiation Therapy: The State of the Art, eds Jatinder Palta and T. Rockwell Mackie (American Association of Physicists in Medicine, College Park MD) pp 247-284, 2003.

Fenwick JD, Tome WA, Jaradat HA, Hui SK, James JA, Balog JP, DeSouza CN, Lucas DB, Olivera GH, Mackie TR, Paliwal BR. Quality assurance of a helical tomotherapy machine. Phys Med Biol. 2004;49:2933-53.

Manon R, Hui S, Chinnaiyan P, Suh J, Chang E, Timmerman R, Phan S, Das R, Mehta M. The impact of mid-treatment MRI on defining boost volumes in the radiation treatment of glioblastoma multiforme. Technology in Cancer Research & Treatment 2004;3:303-7.

Welsh JS, Bradley K, Ruchala KJ, Mackie TR, Manon R, Patel R, Wiederholt P, Lock M, Hui S, Mehta MP. Megavoltage computed tomography imaging: a potential tool to guide and improve the delivery of thoracic radiation therapy. Clin Lung Cancer. 2004;5:303-6.

Forrest LJ, Mackie TR, Ruchala K, Turek M, Kapatoes J, Jaradat H, Hui S, Balog J, Vail DM, Mehta MP The utility of megavoltage computed tomography images from a helical tomotherapy system for setup verification purposes. Int J Radiat Oncol Biol Phys. 2004; 60:1639-44.

Hui SK, Henderson D, Das RK, Thomadsen B. CT based analysis of dose homogeneity in total body irradiation using lateral beam. Journal of Applied Clinical Medical Physics, 2004; 5: 71-79.

Hui SK, Das RK, Kapatoes J, Oliviera G, Becker S, Odau H, Fenwick JD, Patel R, Kuske R, Mehta M, Paliwal B, Mackie TR, Fowler JF, Welsh JS. Helical Tomotherapy as a Means of Delivering Accelerated Partial Breast Irradiation. Technology in Cancer Research and Treatment, 2004; 3: 639-636.

Hui SK, Das RK. Optimization of Conformal Avoidance—A Comparative Study of Prone vs Supine Interstitial High Dose Rate Breast Brachytherapy. Brachytherapy 2005, 4 (2): 137-140.

Hui SK, Kapatoes J, Fowler J, Henderson D, Olivera G, Manon RR, Gerbi B, Mackie TR, Welsh JS. Feasibility Study of Helical Tomotherapy for Total Body or Total Marrow Irradiation. Medical Physics 2005, 32 (10).

Alaei P, Hui SK, Higgins PD, Gerbi BJ. The use of a commercial QA device for daily output check of a helical tomotherapy unit. Med Phys. 2006; 33(10):3680-2.

Hui SK, Verneris MR, Higgins P, Gerbi B, Weigel B, Baker S, Fraser C, Tomblyn M, Dusenbery K. Helical Tomotherapy Targeting Total Bone Marrow—First Clinical Experience at the University of Minnesota. Acta Oncol. 2007;46(2):250-5.

Higgins PD, HAN EY, Yuan JL, Hui S, Lee CK. Evaluation of surface and superficial dose for head and neck treatments using conventional or intensity-modulated techniques. Phys Med Biol. 2007; 52(4):1135-46.

Kalambur Venkat S, Hui Susanta, Bischof John C. Multifunctional magnetic nanoparticles for biomedical applications. Accepted for publication SPIE 2007 (Paper # 6440-33).

Hui SK, Prior J, Gelbart Z, Johnson RR, Lentle BC, Paul M. A Pilot Study of the Feasibility of Long-term Human Bone Balance During Perimenopause Using a 41Ca tracer. Nuclear Instruments and Methods in Physics Research B Nuclear Instruments and Methods in Physics Research B 259 (2007) 796–800.

Levitt SH, Perez CA, Hui S, Purdy JA. Evolution of computerized radiotherapy in radiation oncology: potential problems and solutions. Int J Radiat Oncol Biol Phys. 2008;70(4):978-986.

Blaes AH, Santa-Cruz KS, Lee CK, Hui SK, Peterson BA. Necrotizing leukoencephalopathy following CHOP chemotherapy. Leuk Res. 2008.

Hui Susanta K, PhD, Verneris M R, Froelich Jerry, Dusenbery K, Welsh James S, Multimodality image guided total marrow irradiation and verification of the dose delivered to the lung, PTV and thoracic bone in a patient: A case study. Technology in Cancer Research & Treatment 2009, 1, 23-28.