Research Program: Immunology
Professor, Department of Laboratory Medicine and Pathology

hogqu001@umn.edu
612-625-1616 — office
612-625-1626 — lab
Preferred contact method: Email

Kris Hogquist received her Ph.D. degree in Immunology from Washington University in St. Louis, where she worked with David Chaplin and Emil Unanue. She did postdoctoral training the lab of Michael Bevan at the University of Washington in Seattle. She joined the faculty at the University of Minnesota in 1995.

Research Interests

My lab is interested in the molecular mechanisms of T lymphocyte development, in particular how the T cell receptor interacts with MHC/peptide ligands to result in positive selection (life) or negative selection (death) of the progenitor. Our current approaches include analysis of transgenic and gene deficient mice, gene expression profiling, and RNAi "knock-down" analysis. We are also interested in how peripheral CD8 T cells are tolerized to self-antigens at the barrier surfaces. Understanding how lymphocytes perceive and respond to self-antigens is critical to the development of effective immunotherapy for cancer.

Selected Publication

Weinreich, M.A., Takada K., Skon, C., Reiner, S.L., Jameson, S.C., and K. A. Hogquist. KLF2 deficiency in T cells results in unrestrained cytokine production and bystander chemokine receptor upregulation. Immunity, In Press (2009).

Bursch, L.S., Rich, B.E., and K.A. Hogquist. Langerhans cells are not required for the CD8 T cell response to epidermal self antigen. J. Immunol. 182:4657 (2009).

McCaughtry T.M., Baldwin T.A., Wilken M.S., and K.A. Hogquist. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J.Exp. Med 205:2575 (2008).

Wang L, Bursch LS, Kissenpfennig A, Malissen B, Jameson SC, Hogquist KA. Langerin expressing cells promote skin immune responses under defined conditions. J Immunol. 2008;180:4722-4727.

Hogquist KA, Weinreich MA, Jameson SC. Kruppeled T cells move again. Immunol Cell Biol. 2008;86:297298.

Bursch LS, Wang L, Igyarto B, Kissenpfennig A, Malissen B, Kaplan DH, Hogquist KA. Identification of a novel population of Langerin+ dendritic cells. J Exp Med. 2007;204:3147-56.

McCaughtry TM, Wilken MS, Hogquist KA. Thymic emigration revisited. J Exp Med. 2007;204:2513-20.

Baldwin TA, Hogquist KA. Transcriptional analysis of clonal deletion in vivo. J Immunol. 2007;179:837-44.

Carlson CM, Endrizzi BT, Ding X, Weinreich M, Walsh ER, Wu J, Wani MA, Lingrel JB, Hogquist KA, Jameson SC. Lung Kruppel-like factor (KLF2) regulates thymocyte and T cell migration. Nature 2006;442:299-302.

McNeil LK, Starr TK, Hogquist KA. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci. 2005;102:13574-13579.

Baldwin TA, Sandau MM, Jameson SC, Hogquist KA. The timing of TCRa expression critically influences T cell development and selection. J Exp Med. 2005;202:111-121.

Mick VE, Starr TK, McCaughtry TM, McNeil LK, Hogquist KA. The regulated expression of a diverse set of genes during thymocyte positive selection in vivo. J Immunol. 2004;173:5434-5444.

Mayerova D, Parke EA, Bursch LS, Odumade OA, Hogquist KA. Langerhans cells activate naïve self-antigen specific CD8 T cells in the steady state. Immunity 2004;21:391.