Associate Director, Cancer Prevention and Control
Research Program: Prevention and Etiology Research Programs
Professor, Department of Psychiatry
Adjunct Professor, Division of Epidemiology and Community Health and Department of Psychology
Director, Transdisciplinary Tobacco Use Research Center

hatsu001@umn.edu
612-627-1808 — office
Preferred method of contact: e-mail

Dr. Hatsukami received her Ph.D. from the University of Minnesota in 1980. She was an intern at the University of Washington, Seattle Washington, Department of Psychiatry and Behavioral Sciences from 1977 to 1978.

Research Interests

Dr. Hatsukami has conducted research in the areas of nicotine addiction and treatment of nicotine addiction among a general population of adult smokers as well as adolescents. She has also conducted research in the area of smokeless tobacco. She is currently a Principal Investigator of one of the seven NIH-funded Transdisciplinary Tobacco Use Research Centers (TTURC). The research focus of this TTURC is on methods and understanding mechanisms associated with reducing tobacco toxin exposure. She is a co-recipient of the Ove Ferno award for her research on tobacco dependence. Because of her expertise, she has served on a number of national committees including the National Advisory Council for Substance Abuse and Mental Health Services Administration, National Advisory Council on Drug Abuse, the Interagency Committee for Smoking and Health, Drug Control Research, Data, and Evaluation Committee for the Office of National Drug Control Policy, the Institute of Medicine and was on the Scientific Board of Counselors for the Intramural Research Program of NIDA. She has served on many advisory panels for other federal, non-profit and international organizations. She is a past president of the Society on Research on Nicotine and Tobacco and a past president of the College on Problems of Drug Dependence.

Selected Publications

Hatsukami, D.K., Benowitz, N.L., Rennard, S.I., Oncken, C. & Hecht, S.S. (2006) Biomarkers to assess the utility of potential reduced exposure tobacco products. Nicotine & Tobacco Research, 8(4):599-622.

Stepanov, I., Jensen, J., Hatsukami, D. & Hecht, S.S. (2006) Tobacco-specific nitrosamines in new tobacco products. Nicotine & Tobacco Research, 8(2):309-313.

Hecht, S.S., Carmella, S.G., Yoder, A., Chen, M., Li, Z.Z., Le, C., Dayton, R., Jensen, J & Hatsukami, D.K. (2006) Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolisms in urinary phenanthrene metabolism ratios in smokers. Cancer Epidemiology, Biomarkers and Prevention, 15(10):1805-1811.

Stepanov, I., Feuer, R., Jensen, J., Hatsukami, D. & Hecht, S.S. (2006) Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails. Cancer Epidemiology, Biomarkers and Prevention, 15(12):2378-2383.

Hatsukami, D.K., Le, C.T., Zhang, Y., Joseph, A.M., Mooney, M.E., Carmella, S.G. & Hecht, S.S. (2006) Toxicant exposure in cigarette reducers versus light smokers. Cancer Epidemiology, Biomarkers and Prevention, 15(12):2355-2358.

Hatsukami, D.K., Ebbert, J.O., Anderson, A., Lin, H., Le, C. & Hecht, S.S. (2007) Smokeless tobacco brand switching: A means to reduce toxicant exposure? Drug and Alcohol Dependence, 87(2-3):217-224.

Saccone, S.F., Hinrichs, A.L., Saccone, N.L., Chase, G.A., Konvicka, K., Madden, P.A., Breslau, N., Johnson, E.O., Hatsukami, D., Pomerleau, O., Swan, G.E., Goate, A.M., Rutter, J., Bertelsen, S., Fox, L., Fugman, D., Martin, N., G., Montgomery, G.W., Wang, J.C., Ballinger, D.G., Rice, J.P. & Bierut, L.J. (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3,718 SNPs. Human Molecular Genetics, 16(1):36-49.

Bierut, L.J., Madden, P.A., Breslau, N., Johnson, E.O., Hatsukami, D., Pomerleau, O.F., Swan, G.E., Rutter, J., Bertelsen, S, Fox, L, Fugman, D, Goate, A.M. Hinrichs, A.L, Konvicka, K, Martin, N.G., Mongtomery, G.W., Saccone, N.L, Saccone, S.F., Wang, J.C., Chase, G.A., Rice, J.P. & Ballinger, D.G. (2007) Novel genes identified in a high density genome wide association study for nicotine dependence. Human Molecular Genetics, 16(1):24-35.

Hatsukami, D.K., Mooney, M., Murphy, S., LeSage, M., Babb, D. & Hecht, S. (2007) Effects of high dose transdermal nicotine replacement in cigarette smokers. Pharmacology, Biochemistry and Behavior, 86(1):132-139.

Kotlyar, M, Mendoza-Baumgart, M.I., Li, Z.Z., Pentel, P.R., Barnett, B.C., Feuer, R.M., Smith, E.A. & Hatsukami, D.K. (2007) Nicotine pharmacokinetics and subjective effects of three potential reduced exposure products, moist snuff and nicotine lozenge. Tobacco Control, 16:138-142.

Hecht, S.S., Carmella, S.G., Murphy, S.E., Riley, W.T., Le, C., Luo, X., Mooney, M., & Hatsukami, D.K. (2007) Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers. Cancer Epidemiology, Biomarkers and Prevention, 16(8):1567-72.

Lubin, J.H., Caporaso, N., Hatsukami, D.K., Joseph, A.M., & Hecht, S.S. (2007) The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics. Cancer Epidemiology, Biomarkers and Prevention, 16(9):1852-7

Carmella, S.G., Chen, M., Zhang, Y., Zhang, S., Hatsukami, D.K. & Hecht, S.S. (2007) Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: Effects of cigarette smoking. Chemical Research in Toxicology, 20(7):986-90.

Mendoza-Baumgart, M.I., Tulunay, O.E., Hecht, S.S., Zhang, Y., Murphy, S., Le, C., Jensen, J. & Hatsukami, D. (2007) Pilot study on lower nitrosamine smokeless tobacco products compared to medicinal nicotine. Nicotine & Tobacco Research, 9(12):1309-1323.

Tomar, S.L., & Hatsukami, D.K. (2007) Perceived risk of harm from cigarettes or smokeless tobacco among U.S. high school seniors. Nicotine & Tobacco Research, 9(11):1191-1196.

Hatsukami, D.K., Ebbert, J.O.,  Feuer, R.M., Stepanov, I., & Hecht, S.S. (2007) Changing smokeless tobacco products: New tobacco delivery systems. American Journal of Preventive Medicine, 33(6 Suppl):S368-378.

Hatsukami, D.K., Joseph, A.M., LeSage, M., Murphy, S.E., Pentel, P., Kotlyar, M., Borgida, E., Le, C., & Hecht, S.S. (2007) The science base for reducing tobacco harm reduction. Nicotine & Tobacco Research, 9(Suppl 4): S537-S553.

Baker, T.B., Piper, M.D., McCarthy, D.E., Bolt, D.M., Smith, S.S., Kim, S-Y, Colby, S, Conti, D, Giovino, GA, Hatsukami, D., Hyland, A., Krishnan-Sarin, S., Niaura, R., Perkins, K.A. & Toll, B.A. (2007) Time to first cigarette in the morning as an index of ability to quit smoking: Implications for nicotine dependence. Nicotine & Tobacco Research, 9(Suppl 4): S555-S570.

Hatsukami, D., Ebbert, J.O., Edmonds, A., Li, C., Lin, H., Le, C. & Hecht, S.S. (2008) Smokeless tobacco reduction: Tobacco free snuff vs. no snuff. Nicotine & Tobacco Research. 10(1), 77-85.

Hatsukami, D., Stead, L. F., & Gupta, P. (in press). Tobacco addiction: Diagnosis and treatment. The Lancet.