Research Program: Carcinogenesis & Chemoprevention
Professor, Department of Medicinal Chemistry and Pharmacology
Morse-Alumni Distinguished Teaching

hanna002@umn.edu
612-625-4152 — office
612-624-5184 — lab
Preferred method of contact: e-mail

Research Interests

The Hanna laboratory focuses on investigations of arylamine N-acetyltransferases (NATs), which are enzymes that play critical roles in both the detoxification and toxification (bioactivation) of arylamines. Arylamines are an environmentally important group of agents that are present in tobacco smoke and which are used in the manufacture of drugs, dyes and pesticides. Certain arylamines are known to cause human bladder cancer and others are suspected to be causal factors in lung, breast, colon, and prostate cancer.

Selected Publications

Z. Guo, C.R. Wagner and P.E. Hanna. Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene. Chem. Res. Toxicol. 17, 275-286 (2004).

H. Wang, C.R. Wagner and P.E. Hanna. Irreversible inactivation of arylamine N-acetyltransferases in the presence of N-hydroxy-4-acetylaminobiphenyl: a comparison of human and hamster enzymes. Chem. Res. Toxicol. 18, 183-197 (2005).

H. Wang, L. Liu, P.E. Hanna and C.R. Wagner. Catalytic mechanism of hamster arylamine N-acetyltransferase 2. Biochemistry 44, 11295-11306 (2005).