Research Program: Women's Cancer
Assistant Professor, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, Department of Medicine

gupta014@umn.edu
612-625-7648 — office
612-624-7104 — lab
Preferred method of contact: e-mail

Dr. Gupta obtained her Ph.D. from All India Institute of Medical Sciences, New Delhi. She did her postdoctoral studies at the University of Minnesota in vascular biology. She is currently an assistant professor in the Department of Medicine.

Research Interests

Opioid/opioid receptor signaling in endothelium leading to the pre-clinical and translational studies to investigate the role of opioids and opioid receptor antagonists in angiogenesis, cancer progression and metastasis.

Selected Publications

Gupta K, Kshirsagar S, Schwartz R, Chang L, Law PY, Yee D, Hebbel RP. Morphine stimulates angiogenesis by activating pro-angiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 2002; 62: 4991-8.

Poonawala T, Levay-Young B, Hebbel RP, Gupta K. Opioids heal Ischemic wounds in the Rat. Wound Repair and Regeneration 2005; 13 (2): 165-74.

Farooqui, M, Stephenson JA, Geng Zhen H, Yee D and Gupta K. Naloxone acts as an antagonist of estrogen receptor in MCF7 cancer cells. Mol Cancer Therap 2006; 5(3): 611-20.

Chen C, Farooqui M, Gupta K. Morphine stimulates VEGF-like signaling in mouse retinal endothelial cells. Current Neurovascular Res 2006; 3: 171-180.

Gupta K and Stephenson EJ. Opioid receptors in endothelium. In, The Endothelium: A Comprehensive Reference. Aird WC (Ed). Cambridge University Press, Cambridge, MA. 2006 In Press.

Gupta M, Yunfang Li and Gupta K. Opioids as promoters and regulators of angiogenesis. In, Angiogenesis: Basic Science and Clinical Applications. Maragoudakis ME and Papadimitriou E, Eds.Research Signpost Publishers, Greece. In Press.