Research Program: Women's Cancer
Associate Director, Center for Magnetic Resonance Research
Professor, Department of Medicine

gar@cmrr.umn.edu
612-626-2001 — office

Dr. Garwood received his Ph.D. in chemistry in 1985 from the University of California, Santa Cruz. He conducted postdoctoral training in 1985-1986 at University of California, Santa Cruz, and in 1986-1987 at the University of Minnesota.

Research Interests

My objective is to develop and apply new non-invasive methods in nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) to research cancer. The general aim is to better understand the unique functional and molecular properties of cancer, and to improve the clinical management of the disease, by using MRS/MRI methodologies.

Current specific research goals are threefold:

• To apply theoretical formalisms to describe the magnetic resonance phenomenon.
• To exploit the unique properties of frequency-modulated RF techniques to enhance sensitivity and data quality in MRI and MRS.
• To expose molecular properties of cancers using MRI and MRS, and to use these for making diagnoses and for evaluating and guiding cancer treatments, all non-invasively.

Selected Publications

S. Michaeli, D.J. Sorce, D. Idiyatullin, K. Ugurbil, and M. Garwood, J. Transverse Relaxation in the Rotating Frame Induced by Chemical Exchange. Magn. Reson. 2004; 169: 293-299.

S. Meisamy, P.J. Bolan, E.H. Baker, R.L. Bliss, E. Gulbahce, L.I. Everson, M.T. Nelson, T.H. Emory, T.M. Tuttle, D. Yee, and M. Garwood. Predicting Response to Neoadjuvant Chemotherapy of Locally Advanced Breast Cancer with In Vivo 1H MRS: A Pilot Study at 4 Tesla. Radiology 2004; 233: 424-431.

C.R. Jack, M. Garwood, T.M. Wengenack, B. Borowski, G.L. Curran, J. Lin, G. Adriany, O.H.J. Grö R. Grimm, and J.F. Poduslo. In Vivo Visualization of Alzheimer's Amyloid Plaques by MRI in Transgenic Mice Without a Contrast Agent. Magn. Reson. Med. 2004; 52: 1263-1271.

S. Meisamy, P.J. Bolan, E.H. Baker, M.G. Pollema, C.T. Le, F. Kelcz, M.C. Lechner, B.A. Luikens, R.A. Carlson, K.R. Brandt, K.K. Amrami, M.T. Nelson, L.I. Everson, T.H. Emory, T.M. Tuttle, D. Yee, and M. Garwood. Adding in Vivo Quantitative 1H MR Spectroscopy to Improve Diagnostic Accuracy of Breast MR Imaging: Preliminary Results of Observer Performance Study at 4.0 T. Radiology 2005; 236: 465-475.

M. Marjanska, P.-G. Henry, P.J. Bolan, B. Vaughan, E.R. Seaquist, R. Gruetter, K. Ugurbil, and M. Garwood. Uncovering Hidden In Vivo Resonances Using Editing Based on Localized TOCSY, Magn. Reson. Med. 2005; 53: 783-789.

S. Michaeli, H.I. Grö, O.H.J. Grö, D.J. Sorce, R.A. Kauppinen, C.S. Springer, Jr., K. Ugurbil, and M. Garwood. Exchange-Influenced T2. Contrast in Human Brain Images Measured by Adiabatic RF Pulses. Magn. Reson. Med. 2005; 53: 823-829.

M. Marjanska, G.L. Curran, T.M. Wengenack, P.-G. Henry, R.L. Bliss, J.F. Poduslo, C.R. Jack, Jr., K. Ugurbil, and M. Garwood. Monitoring Disease Progression in Transgenic Mouse Models of Alzheimer's Disease with Proton Magnetic Resonance Spectroscopy. Proc. Natl. Acad. Sci. USA 2005; 102: 11906-11910.

P.J. Bolan, M.T. Nelson, D. Yee, and M. Garwood. Imaging in Breast Cancer: Magnetic Resonance Spectroscopy. Breast Cancer Res. 2005; 7, 149-152.

D. Idiyatullin, C. Corum, J.-Y. Park, and M. Garwood. Fast and Quiet MRI Using a Swept Radiofrequency. J. Magn. Reson. 2006; 181, 342-349.

S. Michaeli, G. Oz, D. Sorce, M. Garwood, K. Ugurbil, and P. Tuite. Assessment of Brain Iron and Neuronal Integrity in Patients with Parkinson's Disease Using Novel MRI Contrasts. Movement Disorders 2007; 22, 334-340.

C.R. Jack Jr, M. Marjanska, T.M. Wengenack, D.A. Reyes, G.L. Curran, J. Lin, G.M. Preboske1, J.F. Poduslo, and M. Garwood. Magnetic Resonance Imaging Alzheimer's Pathology in the Living Brain of Transgenic Mice: A New Tool in Alzheimer's Disease Research. Neuroscientist 2007; 13, 38-48.