Research Program, Prevention and Etiology
Professor, Department of Psychiatry
Senior Scientist, Minneapolis Medical Research Foundation

corri040@umn.edu
612-347-5142 — office
Preferred method of contact: e-mail

Dr. Corrigall began his career as a research scientist at the Addiction Research Foundation and the Department of Physiology at the University of Toronto, where, with internationally derived funding, his research examined mechanisms of dependence in the central nervous system with a primary focus on nicotine and tobacco. Subsequent to this, Dr. Corrigall was director of the Nicotine and Tobacco Addiction Program at the National Institute on Drug Abuse (NIDA) in Bethesda, Md., where he also headed NIDA's Translational Research Branch. In this position his main responsibility was to build program strength at NIDA in nicotine and tobacco research. Currently, he divides his time between a science consulting enterprise based in the Toronto area, and part-time appointments at the University of Minnesota and the Minneapolis Medical Research Foundation.

Research Interests

Discovery of novel biological mechanisms in nicotine dependence, and enabling discovery research and its translation to practice, with particular interest in ways academically based, publicly funded researchers can contribute to expedited development of medications to treat dependence.

Selected Publications

Lerman C, LeSage MG, Siegel, SJ, Perkins KA, O'Malley S, Benowitz N, Corrigall WA. Translational Research in Medication Development for Nicotine Dependence, Nature Revs Drug Disc 6:746-762 (2007).

Ross JT, Corrigall WA, Heidbreder CA, LeSage MG. Effects of the selective dopamine D3 receptor antagonist SB-277011A on the reinforcing effects of nicotine as measured by a progressive-ratio schedule in rats. Eur. J. Pharmacol. 559:173-179 (2007).

Rahman S, Zhang J, Engleman EA, Corrigall WA. Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: a microdialysis study. Neuroscience 129:415-424 (2004).

Rahman S, Zhang J, Corrigall WA. Local perfusion of nicotine differentially modulates somatodendritic dopamine release in the rat ventral tegmental area after nicotine pre-exposure. Neurochem. Res. 29:1687-1693 (2004).

Rahman S, Zhang J, Corrigall WA. Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens. Eur. J. Pharmacol. 21:31-34 (2004).

Rahman S, Zhang J, Corrigall WA. Effects of acute and chronic nicotine on somatodendritic dopamine release of the rat ventral tegmental area: in vivo microdialysis study. Neurosci. Lett. 348:61-64 (2003).

Picciotto MR, Corrigall WA. Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J. Neuroscience (Invited Minireview) 22:3338-3341 (2002).

Corrigall WA, Coen KM, Zhang J and Adamson KL. Pharmacological manipulations of the pedunculopontine tegmental nucleus in the rat reduce self-administration of both nicotine and cocaine. Psychopharmacology 160:198-205 (2002).

Corrigall WA, Coen KM, Zhang J and Adamson KL. GABA mechanisms in the pedunculopontine tegmental nucleus influence particular aspects of nicotine self-administration selectively. Psychopharmacology 158:190-197 (2001).

Corrigall WA, Zack M, Eissenberg T, Belsito L and Scher R. Acute subjective and physiological responses to smoking in adolescents. Addiction 96:1409-1417 (2001).

Zack M, Belsito L, Scher R, Eissenberg T and Corrigall WA. Effects of abstinence and smoking on information processing in adolescent smokers. Psychopharmacology 153:249-257 (2001).

Lança, AJ, Adamson KL, Coen, KM, Chow, BCL and Corrigall WA. The pedunculopontine nucleus and cholinergic regulation of nicotine self-administration in the rat. A correlative neuroanatomical and behavioral study. Neuroscience 96:735-742 (2000).