Research Program: Tumor Biology and Progression
Professor and Chairman, Department of Orthopedic Surgery

clohi001@umn.edu
612-273-8032 — office
612-624-0636 — lab
Preferred contact method: phone

Dr. Clohisy's clinical profile
(University of Minnesota Physicians Web site)

Dr. Clohisy received his M.D. from Northwestern University Medical School in 1983. He conducted a research fellowship at Washington University in 1987 and completed his residency in orthopedic surgery at the University of Minnesota in 1990. After conducting a musculoskeletal oncology fellowship at Harvard Medical School in 1991 he joined the faculty in the Department of Orthopedic Surgery at the University of Minnesota, where he is currently a professor and Chairman. He holds the Roby C. Thompson Endowed Chair in Musculoskeletal Oncology and serves on the University of Minnesota Physicians Board of Directors.

Research Interests

• Development of clinician scientists
• Study of mechanism driving bone cancer pain
• Development of experimental models of bone cancer
• Discovery of novel bone cancer therapies

Selected Publications

Cicek M, Iwaniec UT, Goblirsch MJ, Vrabel A, Ruan M, Clohisy DR, Turner RR, Oursler MJ. 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res. 2007;67:10106-10111.

Ramnaraine ML, Mathews WE, Donohue JM, Lynch CM, Goblirsch MJ, Clohisy DR. Osteoclasts direct bystander killing of bone cancer. Cancer Res. 2006 ;66:10929-10935.

Goblirsch M, Zwolak P, Ramnaraine ML, Pan W, Lynch C, Alaei P, Clohisy DR. Novel cytosine deaminase fusion gene enhances the effect of radiation on breast cancer in bone by reducing tumor burden, osteolysis, and skeletal fracture. Clin Cancer Res. 2006;12:3168-3176.

Selski DJ, Clohisy DR. A customized retroviral vector confers marker gene expression in osteoclast lineage cells. J Cell Biochem. 2006;97:641-650.

Goblirsch M, Lynch C, Mathews W, Manivel JC, Mantyh PW, Clohisy DR. Radiation treatment decreases bone cancer pain through direct effect on tumor cells. Radiat Res. 2005;164:400-408

Ramnaraine ML, Pan WH, Clohisy DR. Osteoclasts direct bystander killing of cancer cells in vitro. Bone 2006;38:4-12.

Pan WH, Mathews W, Donohue JM, Ramnaraine ML, Lynch C, Selski D, Walsh N, Cassady IA, Clohisy DR: Analysis of distinct tartrate-resistant acid phosphatase promoter regions in transgenic mice. J Biol Chem 2005;280: 4888-93.

Goblirsch M, Mathews W, Lynch C, Alaei P, Gerbi BJ, Mantyh PW, Clohisy DR. Radiationtreatment decreases bone cancer pain, osteolysis, and tumor size. Radiation Res. 2003;161;228-234.

Nagarajan R, Clohisy DR, Neglia JP, Yasui Y, Mitby PA, Sklar C, Finklestein JZ, Greenberg M, Reaman GH, Zeltzer L, Robison LL. Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing's sarcoma: the Childhood Cancer Survivor Study. Br J Cancer. 2004 ;91:1858-1865.

Ramnaraine M, Pan W, Goblirsch M, Lynch C, Lewis V, Orchard P, Mantyh P, Clohisy DR. Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Res. 2003 ;63:6847-6854.

Nagarajan R, Neglia JP, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon MA, Tersak JM, Ablin A, Robison LL. Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor study. Cancer. 2003;97:2554-2564.

Luger NM, Honore P, Sabino MA, Schwei MJ, Rogers SD, Mach DB, Clohisy DR, Mantyh PW. Osteoprotegerin diminishes advanced bone cancer pain. Cancer Res. 2001;61:4038-4047.

Honore P, Rogers SD, Schwei MJ, Salak-Johnson JL, Luger NM, Sabino MC, Clohisy DR, Mantyh PW. Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience. 2000;98:585-598.

Honore P, Luger NM, Sabino MA, Schwei MJ, Rogers SD, Mach DB, O'keefe PF, Ramnaraine ML, Clohisy DR, Mantyh PW. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med. 2000;6:521-528.