Research Programs: Carcinogenesis & Chemoprevention
Professor, Hormel Institute

clear007@umn.edu
507-437-9655 — office

Research Interests

The effects of body weight on the development of mammary tumorigenesis, particularly as it relates to postmenopausal breast cancer. Addition studies are underway on the effects of body weight on prostate cancer development.

Selected Publications

Hu X, Juneja SC, Maihle NJ, Cleary MP. Leptin—a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst. 2002;94:1704-11.

Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ. Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med. 2004;229:182-193.

Cleary MP, Grande JP, Maihle NJ. Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice. Int J Obes Relat Metab Disord. 2004;28:956-962.

Ray A, Nkhata KJ, Cleary MP. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol. 2007 Jun;30(6):1499-509.

Cleary MP, Hu X, Grossmann ME, Juneja SC, Dogan S, Grande JP, Maihle NJ. Prevention of mammary tumorignesis by intermittent caloric restriction, does caloric during refeeding modulate the response? Exp Biol Med. 2007;232:70-80.

Dogan S, Hu X, Maihle NJ, Grande JP, Cleary MP. Effects of high fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF- mice. Breast Cancer Res 2007;9:R91-R106.

Grossmann ME, Nkhata KJ, Mizuno NK, Ray A, Cleary MP. Effects of adiponectin on breast cancer cell growth and signaling. Brit J Cancer 2008;98:370-372.

Grossmann, ME, A Ray, S Dogan, N Mizuno, and MP Cleary. Balance of adiponectin and leptin modulates breast cancer cell growth. Cell Res, 18:1154-1156, 2008.

Nkhata, KJ, A Ray, S Dogan, JP Grande and MP Cleary. Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements. Breast Cancer Research Treatment 114: 71-83, 2009.

Bonorden, MJ., OP Rogozina, CM Kluczny, ME Grossmann, PL Grambsch, JP Grande, S Perkins, A Lokshin, and MP Cleary. Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP mice. Nutr.Cancer 61:265-275, 2009.

Bonorden, MJ., OP Rogozina, CM Kluczny, ME Grossmann, JP Grande, A Lokshin, and MP Cleary.  Cross-Sectional analysis of intermittent versus chronic caloric restriction in the TRAMP mouse. The Prostate 69:317-326, 2009.

Cleary, MP and ME Grossmann. Obesity and breast cancer: the estrogen connection. Endocrinology. 2009 Apr 16. [Epub ahead of print].

Wang, L, MJL Bonorden, G-X Li, H-J Lee, H Hu, Y Zhang, JD Liao, MP Cleary and J Lü. Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefits. Cancer Prev Res 2:484-495, 2009.

Nkhata, KJ, A Ray, TF Schuster, ME Grossmann and MP Cleary. Effects of adiponectin and leptin co-treatment on human breast cancer cell growth. Oncology Reports 21:1611-1619, 2009.

Cleary, MP, A Ray, OP Rogozina, S Dogan and ME Grossmann. Targeting the adiponectin-leptin ratio for prevention of postmenopausal breast cancer. Frontiers in Bioscience (in press) 2009.

Cleary, MP, ME Grossmann and A Ray. Obesity and the development of breast cancer. Vet.Pathol. (in press).

Dogan, S, OP Rogozina, A Lokshin, JP Grande and MP Cleary. Effect of chronic vs intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages. Oncology Letters 1: (in press) 2010.