Research Programs: Carcinogenesis & Chemoprevention
Professor, Hormel Institute

clear007@umn.edu
507-437-9655 — office

Research Interests

The effects of body weight on the development of mammary tumorigenesis, particularly as it relates to postmenopausal breast cancer. Addition studies are underway on the effects of body weight on prostate cancer development.

Selected Publications

Grossmann ME, Nkhata KJ, Mizuno NK, Ray A, Cleary MP. Effects of adiponectin on breast cancer cell growth and signaling. Brit J Cancer 2008;98:370-372.

Dogan S, Hu X, Maihle NJ, Grande JP, Cleary MP. Effects of high fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF- mice. Breast Cancer Res 2007;9:R91-R106.

Cleary MP, Hu X, Grossmann ME, Juneja SC, Dogan S, Grande JP, Maihle NJ. Prevention of mammary tumorignesis by intermittent caloric restriction, does caloric during refeeding modulate the response? Exp Biol Med. 2007;232:70-80.

Ray A, Nkhata KJ, Cleary MP. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int J Oncol. 2007 Jun;30(6):1499-509.

Cleary MP, Grande JP, Maihle NJ. Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice. Int J Obes Relat Metab Disord. 2004;28:956-962.

Cleary MP, Juneja SC, Phillips FC, Hu X, Grande JP, Maihle NJ. Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med. 2004;229:182-193.

Hu X, Juneja SC, Maihle NJ, Cleary MP. Leptin—a growth factor in normal and malignant breast cells and for normal mammary gland development. J Natl Cancer Inst. 2002;94:1704-11.