Research Program: Transplant Biology & Therapy
Assistant Professor, Hematology, Oncology and Transplantation (HOT) Division

bruns072@umn.edu

Dr. Brunstein's clinical profile
(University of Minnesota Physicians Web site)

Research Interests

Dr. Brunstein is an assistant professor in the Hematology, Oncology and Transplantation (HOT) Division and works primarily on the Adult Blood and Marrow Transplantation service. Dr. Brunstein received his M.D. in 1990 from the Universidade Federal do Rio Grande do Sul, Brazil. He did his internal medicine residency training and subspecialty training in clinical oncology in Brazil. He subsequently received a Ph.D. in medicine doing research in lung cancer. In 1998, he started a fellowship in hematology and transplantation at the University of Minnesota. During that time his interests shifted toward stem cell biology and bone marrow transplantation, and he completed a bone marrow transplant fellowship at the University of Minnesota. He joined the faculty in 2004.

Dr. Brunstein's clinical interest is the treatment of hematologic malignancies and blood and marrow transplantation. His research interests focus on the use hematopoietic stem cells for treatment of hematologic disorders. He is involved in research investigating the use of alternative sources of hematopoietic stem cells, in special umbilical cord blood, supportive care and related reduced intensity conditioning regimens.

Selected Publications

Majhail NS, Brunstein CG, Tomblyn M, Thomas AJ, Miller JS, Arora M, Kaufman DS, Burns LJ, Slungaard A, McGlave PB, Wagner JE, Weisdorf DJ. Reduced-Intensity Allogeneic Transplant in Patients Older than 55 Years: Unrelated Umbilical Cord Blood Is Safe and Effective for Patients without a Matched Related Donor. Biol of Blood and Marrow Transplantation 2008; 14:282-289.

Brunstein CG, Baker KS, Wagner JE. Umbilical cord blood transplantation for myeloid malignancies. Curr Opin Hematol 2007; 14:162-169

Brunstein CG, Setubal DC, Wagner JE. Expanding the role of umbilical cord blood transplantation. Br J Haematol. 2007 Apr;137(1):20-35.

Brunstein CG, Baker KS, Wagner JE. Umbilical cord blood transplantation for myeloid malignancies. Curr Opin Hematol. 2007 Mar;14(2):162-9.

Brunstein CG, Barker JN, Weisdorf DJ, DeFor TE, Miller JS, Blazar BR, McGlave PB, Wagner JE. Umbilical Cord Blood Transplantation after Non-Myeloablative Conditioning in 110 Adult Patients. Blood 2007, 110:3064.

Jacobson P, Green K, Rogosheske J, Brunstein C, Ebeling B, DeFor T, McGlave P, Weisdorf D. Highly Variable Mycophenolate Mofetil Bioavailability Following Nonmyeloablative Hematopoietic Cell Transplantation. J Clin Pharmacol 2007; 47:6-12

Majhail N, Brunstein CG, Wagner JE. Double Umbilical Cord Blood Transplantation. Curr Opinion Immunol 2006; 18:571-5

Brunstein CG & Wagner JE. Cord Blood Transplantation for Adults. Vox Sanguinis 2006; 91:195-205

Brunstein CG & Wagner JE. Umbilical Cord Blood Transplantation and Banking. Annu Rev Med 2006: 57:403-417.

Brunstein, CG, Weisdorf, DJ, DeFor, T, Barker, JN, Tolar, J, van Burik, JAH, Wagner, JE. Marked Increased Risk of Epstein-Barr Virus-Related Complications with the Addition of Anti-Thymocyte Globulin to a Non-Myeloablative Conditioning prior to Unrelated Umbilical Cord Blood Transplantation. Blood 2006;108: 2874-80

Majhail, NS, Weisdorf, DJ, Wagner, JE, DeFor, TE, Brunstein, CG, Burns, LJ. Comparable results of umbilical cord blood and HLA matched sibling donor Hematopoietic stem cell transplant after reduced-intensity preparative regimen for advanced hodgkin's lymphoma. Blood 2006; 107: 3804-07.

Jacobson P, Long J, Rogosheske J, Brunstein C, Weisdorf D. High umbound mycophenolic acid concentrations in Hematopoietic cell transplantation patient with sepsis and renal and hepatic dysfucntion. Biol Blood Marrow Transplant 2005; 11 977-78.

Askari S, Nollet K, Debol SM, Brunstein CG, Eastlund T. Transfusion-related acute lung injury during plasma exchange: suspecting the unsuspected. Journal of Clinical Apheresis 2002; 17:93-96.

Brunstein CG, Hirsch BA, Hammerschmidt D, McGlennen RC, Nguyen PL, Verfaillie CM. Leukemia in Donor Cells after Allogeneic Hematopoietic Stem Cell Transplant. Bone Marrow Transplantation 2002; 29: 999-1003.

Brunstein CG, Dylla SJ, Verfaillie C. Chromossomal Translocations in Hematologic Malignancies. Current Genomics 2002; 3: 313-334.

Brunstein CG & McGlave P. Chronic myelogenous leukemia: Biology and treatment. Oncology 2001; 15: 23-32.

Brunstein CG, Hirsch B, Miller, J, McGlennen R, Verfaillie C, McGlave P, Weisdorf D. Non-leukemic autologous reconstitution after allogeneic bone marrow transplantation for Ph-positive chronic myelogenous leukemia: extended remission preceding eventual relapse. Bone Marrow Transplantation 2000; 1173-1177.