Masonic Cancer Center

A comprehensive cancer center designated by the National Cancer Institute

Research Studies

The following is a selected list of many research studies conducted by Prevention and Etiology program members. For more information about cancer prevention clinical trials, including tobacco cessation studies and cancer survivorship studies, visit the Find a Clinical Trial page.

Studies in Recruitment
  • Adults In Minnesota with Myelodysplastic Syndrome (AIMMS) Study

    Why is this study being done?
    This study is being done to learn more about myelodysplastic syndrome (MDS).

    This study is an epidemiology study. Typically, epidemiology studies rely on questionnaires to ask people about personal habits, medical history, and other information. The researchers then look for differences between groups of people who develop disease and those who do not. This state-wide epidemiology study is being conducted by the Mayo Clinic, University of Minnesota, and Minnesota Department of Health. Together we are studying factors that may contribute to the development of MDS in adult Minnesotans. We will be working with approximately 700 MDS patients from 2010 to 2014.

    Not a lot is known about why some people develop MDS. The goal of this study is to gather information about personal habits, such as smoking and alcohol use, medical history, and environmental and chemical exposures, from people who have been diagnosed with MDS and compare it to the same information gathered from people who do not have MDS. The doctors and researchers hope that by asking very carefully determined questions of people with and without cancer that they might find a common thread among those who developed MDS (this research is called epidemiology). The researchers also plan to study why some people with MDS sometimes develop leukemia and other people with MDS do not.

    Sponsor
    National Institutes of Health/National Cancer Institute

    Researcher in charge of the study
    Julie A. Ross, Ph.D.
    Masonic Cancer Center, University of Minnesota
    MMC 422 420 Delaware St. SE
    Minneapolis, MN 55455

    Questions?
    Read Information for AIMMS Study Participants, call the study staff at the University of Minnesota toll-free at 1-866-434-9879, or e-mail us at MDSstudy@umn.edu.

  • Germ Cell Tumor Epidemiology Study (GaMETES)

    What is the GaMETES Study?
    The GaMETES (Germ Cell Tumor Epidemiology Study) was designed to try to find out more about risk factors associated with germ cell tumors in children. The main purpose of this study is to understand how genes might affect young people's chances of developing a germ cell tumor (GCT). To do this we will compare the genes of young people with a GCT to the genes of their parents or full siblings. We will also look at how some lifestyle factors work with genes in germ cell tumors. Lastly, if available, we will collect a small part of the leftover tumor sample.

    Who is eligible for this study?
    Families are eligible for this study if:

    1. The child was diagnosed with malignant germ cell tumor after July 1, 2008.
    2. The child was less that 20 years of age when the germ cell tumor was diagnosed .
    3. At least one biological parent is alive and willing to participate.
    4. They can comprehend written English or Spanish.
    5. The child was registered with the Children's Oncology Group and enrolled on ACCRN07.

    How does the study work?
    If a family participates, we will ask for three things: 

    • We will collect some cheek cells from the young person and his/her parents (or a sibling) to look at DNA.
    • We will ask the biological mother and father fill out surveys.
    • If there is left over tumor sample, we will ask for a small portion of it from the Children's Oncology Group tumor bank.  

    Information for GaMETES Study participants: 

    This research will not help you or your family, but it might help us understand why young people get germ cell tumors. Because we don't know what this research might mean for you, we will not give the results of your individual DNA tests to you or your doctor. We will be happy to give you the results of the whole study when it's over.

    Why is this study being done?
    This study is being done to learn more about germ cell tumors and is being conducted by Jenny Poynter , Ph.D., M.P.H. at the University of Minnesota. The participants include:

    • Young people who have been diagnosed with a germ cell tumor
    • Parents of young people who have been diagnosed with a germ cell tumor
    • Brothers or sisters of young people with a germ cell tumor (if one parent cannot participate and the sibling shares the same mother and father)

    Germ cells are reproductive cells that develop into sperm in males and eggs in females. Sometimes germ cells do not develop as they should and an abnormal growth can occur in the testicle or ovary, or in germ cells that have traveled to other areas of the body (such as the chest, abdomen, tailbone or brain). Germ cell tumors can be benign or malignant.

    This is an epidemiologic study, which means that the researchers are gathering information from a lot of families in order to find patterns between potential risk factors they have been exposed to and germ cell tumors. It is known that some environmental factors, such as toxic chemicals, can cause disease. There are some genetic factors in people which can make it more likely for themselves or their children to develop tumors. Some tumors are caused by a combination of factors, including the environment and genetics.

    In this study, both environmental and genetic risk factors are being looked at. Biological parents of young people diagnosed with germ cell tumors are asked to fill out a questionnaire and provide a sample of cheek cells. If one parent is not available to give a cheek cell sample, another son or daughter can instead.

    The DNA from cheek cells may help us discover what genes might be involved in the development of germ cell tumors. Carefully determined questions will ask parents for information related to medical history, family health history, jobs, and their child's health. It must be emphasized that the significance of many of the questions we will ask is entirely unknown. Only by asking questions such as these can we learn whether any of these factors are important in the development of germ cell tumors.

    DNA: Description, collection, storage, and future use

    DNA—what is it? DNA is the genetic material in a person's cells that makes them unique. There are thousands of genes in each cheek cell which are made up of DNA. By studying DNA, scientists can discover what genes might cause young people to get germ cell tumors.

    DNA—collection: The way we collect DNA from you is to have you spit into a sample collection cup that we will provide.

    DNA—storage and future use: We will keep this DNA at our lab for a very long time in case there are things that we want to look at in the future that we haven't thought of yet. You can ask to have your DNA sample destroyed if you want to until 2019. After that we will not have your name and won't be able to tell which DNA sample is yours. If you turn 18 before 2019 we will contact you to ask if we may continue to keep your DNA sample at our lab.

    What are the benefits of participating in the GaMETES Study?
    There will be no direct benefit to you or your family. This research may help us understand why young people get germ cell tumors.

    Can I receive the study results?
    Yes. Group results will be available a few years after the study is completed. When a member of the study staff calls, let her know that you would like to receive the study results.

    When will the study results be available?
    We expect to report the results of this study within a few years after the study is completed. No individual would ever be identified; all data are coded by identification numbers and only group results are presented.

    How can I participate?
    Contact our research team at 1-866-434-9879.

    Sponsor: National Institutes of Health/National Cancer Institute

    Researcher in charge of the study
    Jenny Poynter , Ph.D., M.P.H.
    University of Minnesota Division of Epidemiology/Clinical Research
    Department of Pediatrics
    420 Delaware St. SE MMC 715
    Minneapolis, MN 55455

    More information about germ cell tumors (from the National Cancer Institute PDQ):

    General Information About Extragonadal Germ Cell Tumors

    General Information About Ovarian Germ Cell Tumors

    General Information About Testicular Cancer

Cohort Studies
  • Iowa Women's Health Study

    The Iowa Women's Health Study (IWHS), started in 1986, is a cohort of 41,836 postmenopausal women aged 55-69 at baseline. The primary aims of the study were to:

    1. Determine if the distribution of body fat (waist/hip) predicts incidence of chronic diseases, with the primary endpoints being total mortality, and incident cancers of the breast, endometrium, and ovaries, and
    2. Determine to what degree diet and other lifestyle factors influence risk of chronic disease.

    Questionnaires at baseline (PDF) and for five follow-up surveys (1987, 1989, 1992, 1997, and 2004) provide self-reported information on demographics, reproductive history, medical history, hormone replace therapy, dietary intake (FFQ), physical activity and other factors.

    Annual linkage to the Iowa SEER registry provides cancer incidence and linkage to the National Death Index provides mortality. Self-reported information is used to evaluate risk factors for other endpoints (e.g., diabetes and fractures).

    From 1986 to 2009, there have been 10,144 incident cancers among cohort participants, including over 3,000 breast, 1,300 colon, 1,050 lung, 600 uterine, and 300 ovarian cancers. There have been over 18,800 deaths, including about 5,400 from cancer and 7,006 from cardiovascular disease. Over 300 manuscripts (PDF list) have been published based on analyses in IWHS or based on collaborative projects with Harvard and Oxford Universities, and the NCI Cohort Consortium.

    For a current publication list, email Dr. DeAnn Lazovich, lazov001@umn.edu.

    Contact Information
    Questions about specific endpoints, variables or analyses can be directed to: DeAnn Lazovich, PI, or any of the Iowa co-investigators and collaborators:  Kristin Anderson, Jen Poynter, Wendy Rahn, David Jacobs, or Aaron Folsom (U of MN); James Cerhan and Paul Limburg (Mayo Clinic).

  • Minnesota Adolescent Community Cohort

    The Minnesota Adolescent Community Cohort (MACC) Study is a population-based, observational cohort study that includes 4,295 teenagers aged 12-16 when enrolled in 2000-2001 (3,677 from Minnesota and 618 from comparison states), and an additional 668 Minnesota 12-year-olds enrolled in 2001-2002. The MACC Study is designed to allow multilevel analysis of the influences at the individual, family, community, and state level on tobacco use and the trajectory of tobacco uptake.

    The Minnesota participants were sampled using Random Digit Dial methodology, and are nested in 60 geo-political units (GPUs). The GPUs are a stratified random sample that was selected from the entire state. About 720 participants are surveyed each month to provide a time-series of tobacco prevalence for Minnesota. The study is scheduled to collect information about smoking behaviors, attitudes and environments from each cohort member at 15 points in time (90 statewide observations).

    Currently we are in the middle of the twelfth data collection point for individuals. This cohort study allows us to address important questions about changes in smoking patterns through the transition to young adulthood, long-term effects of tobacco control policies and intervention efforts directed at youth, and cohort differences in smoking patterns and response to tobacco control efforts.

    Contact Information
    Jeanne Forster, Ph.D., forster@epi.umn.edu

  • U.S. Radiologic Technologists Study

    Information on this study is available on the U.S. Radiologic Technologist Study website.

  • Molecular Epidemiology of Prostate Carcinogenesis

    Principal Investigator: Timothy Church, Ph.D.

    This population-based case/control study identified prostate cancer patients from the cancer registries in Minnesota and Wisconsin and a control group of healthy adults from those states' driver's license databases in order to examine biologic and occupational risk factors for the disease. Questionnaires and blood samples were used to collect data not only on lifestyle, dietary, and occupational risk factors, but also on family history, medical care utilization, genetic and genomic factors, and molecular markers. Initial analysis focuses on the interaction of occupational pesticide exposures with both genetic polymorphisms in hormonal pathways and loss of heterozygosity in genes related to DNA repair.

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  • Last modified on May 16, 2013