Masonic Cancer Center, University of Minnesota

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Masonic Cancer Center of the University of Minnesota

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Clinical Pharmacology
Services

Services timeline

Planning

  • Review pharmacology background
  • Pharmacokinetic/pharmacogenetic/pharmacodynamic study design
  • Write pharmacology components of grants and research protocols

Drug and Metabolite Analyses

  • Develop and validate assay methods for sample analysis
  • Human subject biological sample analyses (e.g., blood, plasma, PBMC, tumor)

Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Analyses

  • Pharmacokinetic analyses
  • Pharmacogenetic analyses
  • Pharmacodynamic analyses
  • Results interpretation
  • Author pharmacology components of abstracts, reports, and manuscript(s)

Equipment and Analysis Examples

High-performance liquid chromatography (HPLC) equipment

Generic Picture Box Project

Gemcitabine and metabolite concentration time plots

Gemcitabine
Gemcitabine Triphosphate

Busulfan pharmacogenetics

Busulfan graphic

Post-hoc IV busulfan clearance estimates in patients with GSTA1*A/*A, GSTA1*A/*B and GSTA1*B/*B genotypes. The solid lines represent the means for each genotype.