Masonic Cancer Center

A comprehensive cancer center designated by the National Cancer Institute

Cell Signaling

About the Cell Signaling Program

AHCMCC2 - Image - Lange_Carol

Program Leader: Carol Lange, Ph.D.

Members of this program seek to define and understand the spectrum of altered signaling pathways and their components that contribute to cancer initiation, promotion, and disease progression. The goal is to facilitate the step-wide translation of this knowledge into novel strategies aimed at prevention, early detection, diagnostics and prognosis, and treatment of cancer. Programmatic focus includes the actions of cell surface receptors or nuclear receptors (i.e., steroid hormone receptors) and their ligands (the first messengers), intracellular second messengers, protein kinase cascades, and other signaling molecules that serve as modifiers of signal strength and duration, and the endpoints (substrates) of cell signaling pathways that regulate gene expression (transcription factors and their co-regulators, including DNA modifying enzymes).

Research themes:

  • Nuclear and steroid hormone receptor actions
  • Intracellular signaling and molecular targeted therapies
  • Mechanisms of regulation of gene transcription

The Cell Signaling program holds monthly meetings in which single projects or multiple projects within related topic areas are discussed in an interactive roundtable format:

Program Meeting Schedule
    Research Program members
  • Khalil_Ahmed

    ahmedk@umn.edu
    612-467-2594

    Khalil Ahmed, Ph.D.
    Functional role of protein kinase CK2 in cancer cells, employing prostate cancer and head-and-neck cancer as experimental models.

    Peter_Argenta

    argenta@umn.edu
    612-626-6037

    Peter Argenta, M.D.
    Early events in carcinogenesis and the treatment and prevention of ovarian cancer, with specific interest in using antiangiogenic agents in the management of metastatic tumors.

    Bardwell_Vivian

    bardw001@umn.edu
    612-626-7028

    Vivian Bardwell, Ph.D.
    The role of transcription factors in cancer and development.

    AHCMCC2 - Image - 70x80 - Yue Chen 70x80

    yuechen@umn.edu
    612-626-3340

    Yue Chen, Ph.D.
    Development and application of powerful proteomic technologies in combination with biochemistry, cell biology and computational analysis to understand the dynamic profiles of the PTM networks in various diseases, and reveal the correlation between cellular metabolism and diverse PTM pathways.

    Dehm_Scott

    dehm@umn.edu
    612-625-1504

    Scott Dehm, Ph.D.
    Rose of the androgen receptor in prostate cancer development and progression

    Georg_Gunda

    georg@umn.edu
    612-626-6320

    Gunda Georg, Ph.D.
    Design, synthesis, and evaluation of synthetic and natural product-derived medicinal agents; drug discovery by HTS; new synthetic methods; combinatorial chemistry

    AHCMCC2 - Image - Peter Gordon, M.D., Ph.D. 70x80

    gord0047@umn.edu
    612-625-0711

     

    Peter Gordon, M.D., Ph.D.
    Development of approaches for overcoming bone marrow stromal cell mediated chemoresistance in AML and how factors secreted by cells within the leukemia microenvironment impact leukemia development and response to therapy

    Hallstrom_Timothy

    halls026@umn.edu
    612-626-2905

    Timothy Hallstrom, Ph.D.
    Cellular mechanisms controlling Rb/E2F induced apoptosis during normal proliferation and in cancer development

    Harki_Dan

    daharki@umn.edu
    612-625-8687

    Daniel Harki, Ph.D
    Design, synthesis and biophysical characterization of small molecules that influence cellular function

    Kelekar_Ameeta

    ameeta@umn.edu
    625-3204

    Ameeta Kelekar, Ph.D.
    Pathways of cell survival and death with special emphasis on Bcl-2 family proteins as regulators of these pathways

    Kim_Do-Hyung

    dhkim@umn.edu
    612-626-3418

    Do-Hyung Kim, Ph.D.
    Understanding the molecular networks that coordinate nutrient metabolism and cell growth

    Konety_Badrinath

    brkonety@umn.edu
    612-625-1655

    Badrinath Konedy, M.D., M.B.A.
    Urologic oncology; urinary markers for bladder cancer; new diagnostics techniques for prostate cancer; development of novel agents including gene therapy for prostate cancer

    AHCMCC2 - Image - 70x80 - Lange 70

    lange047@umn.edu
    612-626-0621

    Carol Lange, Ph.D.
    Mechanisms of cancer progression involving signal transduction cross talk with steroid hormone receptors in breast, lung, and ovarian cancer models; role of  MAPKs as major inputs to ligand-dependent and -independent progesterone receptor action and target gene selection in breast cancer; role of  Brk/PTK6 actions upstream of ERK5 and p37 MAPK stress signalling pathways in breast tumor progression/ hypoxia

    AHCMCC2 - Image - 70x80 - Cheuk-Leung

    ctleung@umn.edu

     

    Cheuk T. Leung, Ph.D.
    Mammary tumor initiation from normal tissue, and signaling of tumor dormancy and recurrence utilizing expertise in 3D organotypic models, molecular tool design for single-cell manipulation, 4D live imaging, and 3D screening platform development

    Neufeld_Tom

    neufe003@umn.edu
    612-625-5158

    Thomas Neufeld, Ph.D.
    Developmental mechanisms, genetic mechanisms, cell interactions, signal transduction, cell cycle regulation

    Ostrander_Julie

    hans1354@umn.edu
    612-625-1996

    Julie Ostrander, Ph.D.
    Identification of biomarkers to identify pre-invasive breast cancer and response to chemoprevention

    Polunovsky_Vitaly

    polun001@umn.edu
    612-626-2112

    Vitaly Polunovsky, Ph.D.
    The role of mRNA cap-dependent translation in breast cancer

    Potter_David

    dapotter@umn.edu
    612-625-8933

    David Potter, M.D., Ph.D.
    Potential role for the HIV protease inhibitor, ritonavir, as a modulator of PI2-kinase/AKT signaling in breast cancer and the development of new therapeutic approaches to breast cancer based on its function. Also of interest are the mechanisms of calpain proteases in cell motility and cytoskeletal remodeling.

    Rose-Hellekant_Teresa

    trosehel@d.umn.edu
    218-726-6621

    Teresa Rose-Hellekant, D.V.M., Ph.D.
    Natural history of mammary cancer development; identification of molecular and cellular targets of tamoxifen chemoprevention; role of developmental genes in breast carcinogenesis; anticancer gene therapy and utility of mesenchymal stem cells; mouse modeling of cancer to study novel therapeutic and preventive drugs.

    Sachdev_Deepali

    sachd003@umn.edu
    612-624-0123

    Deepali Sachdev, Ph.D.
    Regulation of breast cancer biology by the insulin-like growth factors (IGFs) and the IGF-1 receptor

    Saluja_Ashok

    asaluja@umn.edu
    612-624-8108

    Ashok Saluja, Ph.D.
    Role of heat shock proteins in the pathophysiology of the resistance of pancreatic cancer to apoptotic cell death.

    Simon_Jeffrey

    simon004@umn.edu
    612-626-5097

    Jeffrey Simon, Ph.D.
    Animal development; control of gene expression; chromatin mechanisms; the role of EZH2 gene in mammary development; epigenetic alterations that cause cancer

    Wagner_Carston R

    wagne003@umn.edu
    612-625-2614

    Carston  Wagner, PhD.
    Rational design of novel anti-cancer therapeutics and nanotechnology based drug delivery systems by employing medicinal organic synthesis, immunology protein engineering, biochemistry and molecular modelling; Characterization of arylamine amine carcinogen metabolizing enzymes

    Yang_Da-Qing

    dyang@hi.umn.edu
    507-279-3048

    Da-Qing Yang, Ph.D.
    Signal transduction of ATM protein kianses in response to insulin and metformin in both diabetes and cancer; mechanisms of tumor suppressor gene function and cancer development, specifically regulation of p53 induction in response to DNA damage.

    Yee_Douglas

    yeexx006@umn.edu
    612-626-8487

    Douglas Yee, M.D.
    Understanding the contribution of insulin-like growth factor (IFG) action to the breast cancer malignant phenotype; experimental new therapies for breast cancer.

    Zarkower_David

    zarko001@umn.edu
    612-625-9450

    David Zarkower, Ph.D.
    DM domain gene function and role in human disease, including testicular cancer.

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  • Last modified on June 19, 2014