Masonic Cancer Center

A comprehensive cancer center designated by the National Cancer Institute

Biostatistics and Bioinformatics

The primary objective of the Biostatistics and Bioinformatics shared resource of the Masonic Cancer Center is to provide centralized biostatistics and bioinformatics supports for all research projects of all members of the Masonic Cancer Center. The shared resource will serve as the focal point from which investigators and their team members at the Masonic Cancer Center can draw biostatistics and bioinformatics expertise for the design and analysis of their research projects.

The aims of the Biostatistics and Bioinformatics shared resource are to:

  1. Provide biostatistics and bioinformatics expertise in study design, including endpoint definition, sample size estimation and power calculation, randomization procedures, data collection from design, plans for report generation, interim reviews, and final analysis.
  2. Provide biostatistics and bioinformatics analyses and informatics support for all cancer research projects using contemporary statistical and computing methodologies.

The Biostatistics and Bioinformatics shared resource is an independent, stand-alone shared resource of the Masonic Cancer Center; it may draw faculty support from the Division of Biostatistics, School of Public Health, if and when it is needed, but it is operating within the Masonic Cancer Center, independent of the Division of Biostatistics. All members, research programs, and other shared resources of the Masonic Cancer Center will be supported by the Biostatistics and Bioinformatics shared resource.

Staff

Biostatistics Director
Chap T. Le, Ph.D.
Professor of Biostatistics
Office: A441 Mayo, Phone: 612-624-9963
Office: 717 Delaware #5, Phone: 612-625-5506
Email: chap@umn.edu

Funding

Limited services are provided free of charge to researchers planning cancer-related grant applications and research protocols, which may include the analysis of cancer-related research data from pilot and feasibility studies.

Extended collaboration with the Biostatistics and Bioinformatics Core should be directly supported by the appropriate funding sources. Costs for services are recovered through percent effort of personnel. Investigators should include either a team of statisticians as a Biostatistics Core in applications of program projects or specific core member as co-investigator in applications of other grants.

Publications resulting from statistic or bioinformatics work should merit co-authorship: the order of authorship is up to the principal investigator/primary author.

The primary aim of the Biostatistics staff is to support funded cancer-related projects of Cancer Center members; support of other projects can be arranged. The staff supports several program projects (P- and U- grants, and SOPRES). We provide Cancer Center members with a high level and broad range of expertise in data management and biostatistics.

Investigators are encouraged to initiate collaboration with the Biostatistics staff as early as possible in the protocol planning process and to utilize services throughout the duration of their projects.

Biostatistics Services

Services include support in the planning, monitoring, and analysis phases of a study.

Planning

  • Review background and rationale
  • Identify hypotheses, endpoints, and covariates
  • Design experiments and surveys
  • Estimate sample size and calculate power
  • Assist database development
  • Write statistical considerations components of grants and research protocols
  • Develop early stopping rules for clinical trials
  • Monitoring

Process, store, and retrieve data

  • Monitor accrual
  • Conduct interim analysis
  • Assist with continuation/stopping decisions

Analysis

  • Conduct statistical analysis
  • Assist with interpretation of results
  • Recommend presentation methods
  • Author statistical analysis component of manuscripts

Complete a Biostatistics Services form (Word document)

Contact Information

Coordinator

Bruce R. Lindgren, M.S.
Office: 717 Delaware, Room 133
Campus Mail Code 1932
612-624-2939
lindg001@umn.edu

Faculty

Director:
Chap T. Le, Ph.D.
Distinguished Teaching Professor of Biostatistics
Office: A441 Mayo
Campus Mail Code 8-303
612-624-9963
chap@umn.edu

Dipanker Bandyopadhyay, Ph.D.
Associate Professor of Biostatistics
Office: A452 Mayo
Campus Mail Code 8-303
612-625-9142
dbandyop@umn.edu

Haitao Chu, Ph.D.
Associate Professor of Biostatistics
Office: A426 Mayo
Campus Mail Code 8-303
612-625-2138
chux0051@umn.edu

Yen-Yi Ho, Ph.D
Assistant Professor of Biostatistics
Office: A448 Mayo
Campus Mail Code 8-303
612-624-7656
yho@umn.edu

Joseph Koopmeiners, Ph.D.
Assistant Professor of Biostatistics
Office: Mayo A-454-2
Campus Mail Code 8-303
612-624-7486
koopm007@umn.edu

Xianghua Luo, Ph.D.
Assistant Professor of Biostatistics
Office: A455 Mayo
Campus Mail Code 8-303
612-624-2158
luox0054@umn.edu

Professional Academic Staff

Robin L. Bliss, M.S.
Senior Research Fellow
Office: 717 Delaware, Room 136
Campus Mail Code 1932
612-624-7176
bliss003@umn.edu

Qing Cao, M.S.
Research Fellow
Office: 717 Delaware, Room 130
Campus Mail Code 1932
612-624-2604
caox0075@umn.edu

Todd DeFor, M.S.
Senior Research Fellow
Office: 717 Delaware Room 144C
Campus Mail Code 1932
612-626-6846
defor001@umn.edu

Rachel Isaksson Vogel, M.S.
Research Fellow
Office: 717 Delaware, Room 130
Campus Mail Code 1932
612-624-6928
isak0023@umn.edu

Bruce R. Lindgren, M.S.
Senior Research Fellow
Office: 717 Delaware, Room 133
Campus Mail Code 1932
612-624-2939
lindg001@umn.edu

Ryan Shanley, M.S.
Research Fellow
Office: 717 Delaware, #4
Campus Mail Code 1932
shan0219@umn.edu

Yan Zhang, M.S.
Research Fellow
Office: 717 Delaware Room 136
Campus Mail Code 1932
612-624-6916
zhang254@umn.edu

With a focus on data associated with a large-scale molecular studies, our services are developed on an ad hoc basis depending on the needs of the given researcher. These needs may be as straightforward as working with researchers to access tools available within the University (such as those provided by the Minnesota Supercomputing Institute) or outside the University. More often, our staff members may serve as collaborative partners in the development of custom databases and analysis pipelines involving large data sets generated in high throughput projects.

Requests for assistance will be placed in order of priority as listed below:

  • Projects that provide funding for Bioinformatics experts in the core
  • Grant preparation
  • Data analysis for cancer-related projects
Services We Offer

Planning

  • Design experiments involving large-scale molecular studies
  • Referrals to MSI software and staff for other molecular studies
  • Referrals to external software sources (e.g., EnsEMBL, FANTOM)
  • Write bioinformatic components of grant proposals
  • Identify leading-edge technologies to be incorporated in research plans
     

Analysis

  • Conduct analysis of high throughput molecular data (e.g., mRNA, miRNA, insertional mutagenesis studies, ChIP-seq)
  • Assist with the interpretation of results
  • Recommend presentation and visualization methods
  • Author bioinformatics component of manuscripts

Complete a request form for Bioinformatics services (Word document)

Contact Information

Coordinator/Bioinformatics Research Scientist
Aaron Sarver, Ph.D.
Office: Mayo B-412-3
612-624-2445
sarver@umn.edu

Bioinformatics Research Scientist
Nuri A. Temiz Ph.D.
Office: Mayo B412-2
612-626-6977
temizna@umn.edu

 

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  • Last modified on June 4, 2013