Cancer Center Update is sent to Cancer Center members and staff every Tuesday at 10 a.m. Please submit items to Sandi Sherman, sherm019@umn.edu, by noon the previous Friday.

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In This Issue

Today's Cancer Center Seminar

News

Education and Events

Cancer Center Program Meetings

Funding News and Opportunities

 

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Today's Cancer Center Seminar

Tuesday, November 27, 2007, 12-1 p.m., 450 CCRB
Cellular control of Rb/E2F induced proliferation and apoptosis in cancer
Timothy C. Hallstrom, Ph.D., Assistant Professor, Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplantation, University of Minnesota

A peek at next week's seminar:
Tuesday, December 4, 2007, 12-1 p.m., 450 CCRB
Circulating and resident endothelial colony forming cells
Mervin C. Yoder, Jr., M.D., Richard and Pauline Klingler Professor, Department of Pediatrics, Indiana University School of Medicine

Host: Bruce Blazar, M.D.

Visit the Cancer Center Seminar Series calendar for a complete schedule of lectures.

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News

Cleary presented at American College of Veterinary Pathology annual meeting
Margot Cleary, Ph.D., Carcinogenesis and Chemoprevention Program member and Professor, Hormel Institute, presented "The effect of obesity on breast cancer development" at the American College of Veterinary Pathology annual meeting in Savannah, Ga., on November 12.

Cancer Center researchers to present at annual AACR Frontiers in Cancer Prevention Research conference
Several additional Cancer Center researchers will present posters at the American Association of Cancer Research (AACR) Frontiers in Cancer Prevention Research conference in Philadelphia, December 5-8, 2007. For a complete list of presenters visit our Web site.

Melissa Bonorden, M.S., Assistant Scientist, Cleary lab, "Cross-sectional analysis of intermittent versus chronic caloric restriction in the TRAMP mouse model of prostate cancer"

Katai Nkhata, M.S., Junior Scientist, Cleary lab, "Leptin and adiponectin effects on an ovarian cancer cell line OV-90 which provide insights into obesity's role in ovarian cancer"

Olga Rogozina, M.D., Ph.D., Postdoctoral Fellow, Cleary lab, "Protective effect of intermittent versus chronic calorie restriction on mammary tumor development in relationship to prospective IGF-1 serum concentrations in MMTV-TGF-alpha mice"

Michael Grossmann, Ph.D., Research Assistant Professor, Cleary lab, "Characterization of adiponectin receptor expression and function in TRAMP prostate tumors and the TRAMP-C2 cell line"

Cancer Center researchers to present at ASH meeting
Cancer Center researchers and University of Minnesota colleagues will be among the presenters at the American Society of Hematology (ASH) meeting in Atlanta December 8-12, 2007. If you or someone from your laboratory is giving an oral or poster presentation at ASH, and you have not been listed yet, please e-mail Gina Kennedy, kenne069@umn.edu, to be included on the list and in a future edition of Update. For a complete list of presenters visit our Web site.

Oral Presentations:

Frank Cichocki, Miller lab, "STAT5 overexpression enhances killer immunoglobulin receptor (KIR) expression in developing NK dells and is associated with a loss of reverse transcription from the proximal KIR promoter"

Sarah Cooley, M.D., Assistant Professor, Medicine HOT, "Activating KIR (B Haplotype) in unrelated donors improves disease-free survival after HLA-matched and mismatched allogeneic transplantation for acute myeloid leukemia: Implications for donor selection using KIR genotyping"

Milena Elimelakh, M.D., Assistant Professor, Medicine HOT, "Incidence and outcomes of immune thrombocytopenia (ITP) following hematopoietic stem cell transplantation (HCT)"

Lisa Jasperson, Blazar lab, "Indoleamine 2,3-dioxygenase is a critical regulator of acute GVHD"

Maki Shindo, M.D., Ph.D., Chen lab, Pediatric BMT, "Toll-like receptor agonists induce immunogeneicity and apoptosis of acute myeloid leukemia cells"

Jakub Tolar, M.D., Ph.D., Pediatric BMT, "Glycosaminoglycans as anticoagulants in mucopolysaccharidosis Type I (MPS I)"

Poster presentations:

Robert Godal, M.D., Miller lab, "Killer immunoglobulin receptor (KIR) negative NK cells exhibit potent alloreactivity against primary leukemia targets when interrupting MHC class I interactions through NKG2A blockade"

Sonja Johnson, LeBien lab, "CD127 expression confers enhanced survival on human B-lineage cells: Implications for the role of IL-7 signaling in human B lymphopoiesis." (Johnson is also a recipient of an ASH travel award for this meeting.)

Angie Smith, M.D., Fellow, Pediatric BMT, "Reversible bony changes after treatment with bevacizumab in a child with cutaneovisceral angiomatosis with thrombocytopenia syndrome: A case report and review of the literature"

Petter Woll, Kaufman lab, "NK cells derived from human embryonic stem cells demonstrate more effective in vivo clearance of xenografted human tumor cells compared to NK cells derived from cord blood"

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Education and Events

Cancer Biology Journal Club
Wednesday, November 28, 2007, 12-1 p.m., 2-120 Moos Tower
Joan Beckman, MD/PhD student, will discuss "A role for iron in Wnt signaling," Oncogene 2007, August 13 [E-pub ahead of print].

The Cancer Biology Journal Club is held every Wednesday. For more information contact Sonja Johnson (john4368@umn.edu) or Rachel Bergerson (sapl0005@umn.edu).

Cancer Center Staff and Faculty Recognition Program
Wednesday, November 28, 2007, 2 p.m., 450 CCRB
Cancer Center faculty and staff are invited to the quarterly Recognition Program. This event will focus on activities and research in Population Sciences. A recognition award will be presented to an individual or group for their outstanding contribution to the Cancer Center's mission. Refreshments will be served.

Special Seminar
Friday, November 30, 2007, 11:30 a.m.-12:30 p.m., 450 CCRB
For questions, contact Ginny Oie, 626-2902.
Primary prevention of cardiovascular disease: Detecting and treating endothelial activation in children
Aaron Kelly, Ph.D. Assistant Professor, Department of Pediatrics, University of Minnesota.

Dr. Kelly is a candidate for assistant/associate professor (tenure-track) in Pediatric Epidemiology and Clinical Research.

Cancer Outcomes and Survivorship Research Group Seminar
Monday, December 3, 2007. 12-1 p.m., Moos Tower 2-118
Clinical Survivorship Program - a research resource
Daniel A. Mulrooney, M.D., M.S., Assistant Professor, Pediatric Hematology/Oncology and Bone Marrow Transplantation

Please RSVP to drei0022@umn.edu by Friday, November 30 if you want lunch.

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Cancer Center Program Meetings

Genetic Mechanisms of Cancer Program Seminar
Thursday, November 29, 2007, 4-5 p.m., 3-110 Moos Tower
A forward genetic screen for gastrointestinal tract cancer genes
Tim Starr, Ph.D. Postdoctoral Associate, Largaespada lab

For a complete schedule, visit the Web site.

Cancer Biology Research Club
Friday, November 30, 2007, 3:30-4:30 p.m., 450 CCRB
A systematic approach for prostate cancer gene identificaton
Eric Rahrmann, Cancer Biology Training Grant Predoctoral Fellow, Marker lab

For a complete schedule, visit the Web site.

BMT Conference
Monday, December 3, 2007, 1:15-2:15 p.m., 450 CCRB
Research Updates - ASH oral presentations
Umbilical cord blood T cells express the natural cytotoxicity receptors, NKp30, NKp44 and Nkp46 after IL-15 stimulation, but only NKp30 is functional
Michael Verneris, M.D., Assistant Professor, Pediatric H/O/BMT

Induction of skin repair mechanism by bone marrow derived SLAM family receptor enriched cells in murine epidermolysis bullosa
Jakub Tolar, M.D., Ph.D., Assistant Professor, Pediatric H/O/BMT

Classification of HLA-natching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival
Daniel Weisdorf, M.D., Professor, HOT

TLR agonists induce immunogeneicity and apoptosis of acute myeloid leukemia cells
Maki Shindo, M.D., Ph.D., (Chen Lab), Pediatric BMT

For a complete schedule, visit the Web site.

 

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Funding News and Opportunities

No funding news or grant announcements were submitted to Update this week.

Visit the Funding News & Opportunities Web page to see listings previously published in Update.

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