Removal of a small disk-shaped sample of tissue using a sharp, hollow device. The tissue is then examined under a microscope.

Punch biopsy. A hollow, circular scalpel is used to cut into a lesion on the skin. The instrument is turned clockwise and counterclockwise to cut down about 4 millimeters (mm) to the layer of fatty tissue below the dermis. A small sample of tissue is removed to be checked under a microscope. Skin thickness is different on different parts of the body.
2004-12-222008-10-17